CAJ | 학술논문

目的调查中老年人群高尿酸血症(HUA)的患病率以及影响因素.方法分层随机整群抽样,横断面调查青岛市湛山社区40～74岁居民1706名,问卷调查,体格检查,检测空腹血尿酸(SUA)、血脂、血糖等.结果 (1)调整年龄后SUA水平均值为342.6μmol/L(男388.0μmol/L,女317.6μmol/L),同年龄组男性SUA显著高于女性,仅女性SUA水平随年龄增长呈总体上升趋势(P<0.01).(2)HUA的粗患病率为25.1%.按2000年全国人口普查年龄构成计算,男女HUA标化患病率分别为29.5%和20.5%%,标化患病率分别为23.3%.(3)多因素线性回归结果表明,BMI、TG、BP、饮酒、增龄与SUA相关性最高.结论青岛市社区居民HUA患病率较高,肥胖、脂代谢异常、高血压、饮酒、高嘌呤饮食和增龄是影响SUA的重要相关因素.
목적 조사중노년인군고뇨산혈증(HUA)적환병솔이급영향인소.방법분층수궤정군추양,횡단면조사청도시담산사구40～74세거민1706명,문권조사,체격검사,검측공복혈뇨산(SUA)、혈지、혈당등.결과 (1)조정년령후SUA수평균치위342.6μmol/L(남388.0μmol/L,녀317.6μmol/L),동년령조남성SUA현저고우녀성,부녀성SUA수평수년령증장정총체상승추세(P<0.01).(2)HUA적조환병솔위25.1%.안2000년전국인구보사년령구성계산,남녀HUA표화환병솔분별위29.5%화20.5%%,표화환병솔분별위23.3%.(3)다인소선성회귀결과표명,BMI、TG、BP、음주、증령여SUA상관성최고.결론 청도시사구거민HUA환병솔교고,비반、지대사이상、고혈압、음주、고표령음식화증령시영향SUA적중요상관인소.
Objective To estimate the prevalence of hyperuricemia (HUA) and risk factors for HUA in a Chinese population of Qingdao city community. Methods A cross-sectional population survey for hyperuricemia was performed in 2002. Questionnaire were conducted in 1706 subjects, and levels of serum UA, lipid-profile, as well as height, weight, blood pressure were measured. Hyperuricemia was defined as serum UA levels >420 μmol/l in men and >360 μmol/l in women. All statistical analyses were performed using SPSS. Results Age-adjusted mean serum UA level was 388.0μmol/l in men and 317.6μmol/l in women. Serum UA was increased with age in women only (P for trend <0.001). The age-standardized prevalence was 23.3% for hyperuricemia in adults aged 40 to 74 years. Hyperuricemia was more in men than in women (29.5% vs 20.5%, P<0.001). In multivariate regression analysis, serum UA was significantly and independently associated with BMI, triglyceride and alcohol drinking in men, and these variables explained 15.0% of the variation in serum UA. In women, UA was correlated directly with BMI, triglyceride, total cholesterol and systolic blood pressure, which accounted for 13.0% of serum UA variations. Conclusions The prevalence of hyperuricemia in the urban adult population in Qingdao city is high.Obesity, hypertension, and dyslipidemia are the major factors associated with serum UA. Interventions by limiting the purine-rich foods to prevent a further increase in hyperuricemia may simultaneously reduce the risk for cardiovascular disease