中华航空航天医学杂志
中華航空航天醫學雜誌
중화항공항천의학잡지
CHINESE JOURNAL OF AEROSPACE MEDICINE
2009年
1期
10-18
,共9页
王林杰%魏金河%曹毅%张丹%郭建平%唐国华%赵琦
王林傑%魏金河%曹毅%張丹%郭建平%唐國華%趙琦
왕림걸%위금하%조의%장단%곽건평%당국화%조기
前庭%听觉%事件相关电位,P300%心率%茶苯海明%异丙嗪%盐酸地芬尼多%药物评价
前庭%聽覺%事件相關電位,P300%心率%茶苯海明%異丙嗪%鹽痠地芬尼多%藥物評價
전정%은각%사건상관전위,P300%심솔%다분해명%이병진%염산지분니다%약물평개
Vestibule%Auditory perception%Event-related potentials,P300%Heart rate%Dimenhydrinate%Promethazine%Difenidol hydrochloride%Drug evaluation
目的 空间运动病是载人航天飞行不可规避的医学问题之一,目前服用抗运动病药物是较为有效的预防方法.但大多数抗运动病药物均对认知功能有一定影响,且其影响在前庭刺激下会有所改变.为良好地指导航天医学实践,本试验比较了口服3种抗运动病药物(盐酸地芬尼多、茶苯海明、盐酸异丙嗪)对前庭刺激下听觉认知和自主神经反应活动的影响. 方法 采用拉丁方试验设计、严格双盲给药,对8名受试者进行了定最前庭刺激,前庭刺激的同时要求受试者完成听觉认知任务.记录受试者完成认知任务的脑电信号,采用事件相关电位技术提取完成认知任务的P3成分.对口服安慰剂和不同抗运动病药物下P3成分潜伏期和峰值波幅进行了比较. 结果 抑制前庭自主神经反应的顺序为盐酸异丙嗪、茶苯海明、盐酸地芬尼多、安慰剂;对前庭刺激下脑认知过程的影响从强到弱为盐酸异丙嗪、茶苯海明、安慰剂、盐酸地芬尼多. 结论 在同样前庭刺激下盐酸地芬尼多对自主神经系统反应有调节作用,对前庭刺激下脑认知过程影响较弱,是温和作用药物,也是在非严重运动病爆发下的首选药物.
目的 空間運動病是載人航天飛行不可規避的醫學問題之一,目前服用抗運動病藥物是較為有效的預防方法.但大多數抗運動病藥物均對認知功能有一定影響,且其影響在前庭刺激下會有所改變.為良好地指導航天醫學實踐,本試驗比較瞭口服3種抗運動病藥物(鹽痠地芬尼多、茶苯海明、鹽痠異丙嗪)對前庭刺激下聽覺認知和自主神經反應活動的影響. 方法 採用拉丁方試驗設計、嚴格雙盲給藥,對8名受試者進行瞭定最前庭刺激,前庭刺激的同時要求受試者完成聽覺認知任務.記錄受試者完成認知任務的腦電信號,採用事件相關電位技術提取完成認知任務的P3成分.對口服安慰劑和不同抗運動病藥物下P3成分潛伏期和峰值波幅進行瞭比較. 結果 抑製前庭自主神經反應的順序為鹽痠異丙嗪、茶苯海明、鹽痠地芬尼多、安慰劑;對前庭刺激下腦認知過程的影響從彊到弱為鹽痠異丙嗪、茶苯海明、安慰劑、鹽痠地芬尼多. 結論 在同樣前庭刺激下鹽痠地芬尼多對自主神經繫統反應有調節作用,對前庭刺激下腦認知過程影響較弱,是溫和作用藥物,也是在非嚴重運動病爆髮下的首選藥物.
목적 공간운동병시재인항천비행불가규피적의학문제지일,목전복용항운동병약물시교위유효적예방방법.단대다수항운동병약물균대인지공능유일정영향,차기영향재전정자격하회유소개변.위량호지지도항천의학실천,본시험비교료구복3충항운동병약물(염산지분니다、다분해명、염산이병진)대전정자격하은각인지화자주신경반응활동적영향. 방법 채용랍정방시험설계、엄격쌍맹급약,대8명수시자진행료정최전정자격,전정자격적동시요구수시자완성은각인지임무.기록수시자완성인지임무적뇌전신호,채용사건상관전위기술제취완성인지임무적P3성분.대구복안위제화불동항운동병약물하P3성분잠복기화봉치파폭진행료비교. 결과 억제전정자주신경반응적순서위염산이병진、다분해명、염산지분니다、안위제;대전정자격하뇌인지과정적영향종강도약위염산이병진、다분해명、안위제、염산지분니다. 결론 재동양전정자격하염산지분니다대자주신경계통반응유조절작용,대전정자격하뇌인지과정영향교약,시온화작용약물,야시재비엄중운동병폭발하적수선약물.
Objective Space motion sickness is one of the inevitable problems that space medicine should face to. At present the administering anti-motion sickness drugs is the most widely used prevention and therapy path. But nearly all drugs have side effects on cognitive function and those effects would be changed by vestibular stimuli. Effects of three anti-motion sickness drugs (difenidol hydrochloride, dimenhydrinate and promethazine hydrochloride) on vestibular-cognitive interaction and vestibular autonomic response were explored. Methods The experiment was done along with 4 × 4Latin Square design and the double blind medication. Eight male volunteers were exposed to vestibular stimuli after administering drugs for 30-40 minutes. They were asked to complete auditory cognitive task during vestibular stimuli under the monitoring of electroencephalogram and electrocardiogram.The P3 component of event-related potentials and heart rate variability parameters were analyzed upon different drugs. Results The order of vestibular autonomic responses inhibition was promethazine hydrochloride, dimenhydrinate, difenidol hydrochloride, placebo, and the order of vestibular-cognitive processing inhibition was promethazine hydrochloride, dimenhydrinate, placebo, difenidol hydrochloride. Conclusions It is suggested that difenidol hydrochloride would be the first choice in case of same vestibular stimuli and less severe motion sickness symptoms.
