中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
3期
3-6
,共4页
C反应蛋白质%葡糖耐量试验%糖尿病,2型
C反應蛋白質%葡糖耐量試驗%糖尿病,2型
C반응단백질%포당내량시험%당뇨병,2형
C-reactive protein%Glucose tolerance test%Diabetes mellitus,type 2
目的 比较不同糖耐量受试者血清超敏C反应蛋白(hs-CRP)水平,探讨hs-CRP检测在糖耐量减低(IGT)及糖尿病患者中的作用.方法 所有受试者均行口服葡萄糖耐量试验(OGTT),用免疫透射比浊法测定正常糖耐量(NGT)、IGT、2型糖尿病(T2DM)受试者血清hs-CRP水平.结果 NGT、IGT和T2DM者血清hs-CRP水平分别为(1.57±0.46)、(2.84±0.48)、(4.18±0.76)mg/L,hs-CRP分别与体重指数、收缩压、舒张压、空腹血糖、OGTT试验中2h血糖、三酰甘油和总胆固醇呈正相关.结论 T2DM患者早在IGT阶段就已经存在炎性反应,炎性反应可能参与了T2DM的发生和发展.hs-CRP作为炎性反应因子,在预测和监视T2DM方面有重要意义.
目的 比較不同糖耐量受試者血清超敏C反應蛋白(hs-CRP)水平,探討hs-CRP檢測在糖耐量減低(IGT)及糖尿病患者中的作用.方法 所有受試者均行口服葡萄糖耐量試驗(OGTT),用免疫透射比濁法測定正常糖耐量(NGT)、IGT、2型糖尿病(T2DM)受試者血清hs-CRP水平.結果 NGT、IGT和T2DM者血清hs-CRP水平分彆為(1.57±0.46)、(2.84±0.48)、(4.18±0.76)mg/L,hs-CRP分彆與體重指數、收縮壓、舒張壓、空腹血糖、OGTT試驗中2h血糖、三酰甘油和總膽固醇呈正相關.結論 T2DM患者早在IGT階段就已經存在炎性反應,炎性反應可能參與瞭T2DM的髮生和髮展.hs-CRP作為炎性反應因子,在預測和鑑視T2DM方麵有重要意義.
목적 비교불동당내량수시자혈청초민C반응단백(hs-CRP)수평,탐토hs-CRP검측재당내량감저(IGT)급당뇨병환자중적작용.방법 소유수시자균행구복포도당내량시험(OGTT),용면역투사비탁법측정정상당내량(NGT)、IGT、2형당뇨병(T2DM)수시자혈청hs-CRP수평.결과 NGT、IGT화T2DM자혈청hs-CRP수평분별위(1.57±0.46)、(2.84±0.48)、(4.18±0.76)mg/L,hs-CRP분별여체중지수、수축압、서장압、공복혈당、OGTT시험중2h혈당、삼선감유화총담고순정정상관.결론 T2DM환자조재IGT계단취이경존재염성반응,염성반응가능삼여료T2DM적발생화발전.hs-CRP작위염성반응인자,재예측화감시T2DM방면유중요의의.
Objective To investigate,the significance of serum high-sensitivity C-reactive protein (hs-CRP) concentration in subjects with various glucose tolerance and study the role of hs-CRP in patients of impaired glucose tolerance (IGT) and diabetes mellitus.Method All subjects in the study underwent oral glucose tolerance test (OGTT).Determination of serum hs-CRP levels in normal glucose tolerance(NGT),IGT and type 2 diabetes mellitus (T2DM) patients were made by immunologic projective turbidimetry method.Results The levels of serum hs-CRP were (1.57 + 0.46) mg/L in NGT patients,(2.84 ±0.48) mg/L in IGT patients,and(4.18± 0.76) mg/L in T2DM patients.The levels of serum hs-CRP were positively correlated with body mass index,systolic blood pressure,diastolic blood pressure,fasting plasma glucose,OGTr 2 hPG,triglyceride,and total cholesterol.ConclusionsInflammation has already existed not only in T2DM patients but also in subjects with IGT.Inflammation might participate in the oeeurrance and development of T2DM.hs-CRP as an inflammator factor can be used to predict and monitor T2DM.
