中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2011年
7期
503-505
,共3页
胃肿瘤,进展期%新辅助化疗%术后并发症%肺部感染
胃腫瘤,進展期%新輔助化療%術後併髮癥%肺部感染
위종류,진전기%신보조화료%술후병발증%폐부감염
Stomach neoplasms,advanced%Neoadjunvant chemotherapy%Postoperative complications%Pneumonia
目的 探讨新辅助化疗对进展期胃癌患者术后肺部感染的影响.方法 按随机数字表法将2009年1月至2011年1月间在南京军区南京总医院接受治疗的139例伴有淋巴结转移的胃癌病例(排除术前重度肺功能障碍者),随机分为新辅助化疗组[69例,动静脉结合新辅助化疗(静脉用药:氟尿嘧啶、亚叶酸;动脉介入:奥沙利铂、表阿霉素、依托泊甙)1个半疗程后接受手术]和直接手术组(70例),比较两组病例术后肺部感染的发生情况.结果 两组病例术前一般情况的比较差异无统计学意义(均P>0.05).所有病例均顺利实施D2胃癌根治手术,术后新辅助化疗组和直接手术组分别有8例(11.6%)和9例(12.9%)患者出现肺部感染,差异无统计学意义(P>0.05).结论 动静脉结合新辅助化疗不会增加胃癌患者术后肺部感染发生率,可安全应用.
目的 探討新輔助化療對進展期胃癌患者術後肺部感染的影響.方法 按隨機數字錶法將2009年1月至2011年1月間在南京軍區南京總醫院接受治療的139例伴有淋巴結轉移的胃癌病例(排除術前重度肺功能障礙者),隨機分為新輔助化療組[69例,動靜脈結閤新輔助化療(靜脈用藥:氟尿嘧啶、亞葉痠;動脈介入:奧沙利鉑、錶阿黴素、依託泊甙)1箇半療程後接受手術]和直接手術組(70例),比較兩組病例術後肺部感染的髮生情況.結果 兩組病例術前一般情況的比較差異無統計學意義(均P>0.05).所有病例均順利實施D2胃癌根治手術,術後新輔助化療組和直接手術組分彆有8例(11.6%)和9例(12.9%)患者齣現肺部感染,差異無統計學意義(P>0.05).結論 動靜脈結閤新輔助化療不會增加胃癌患者術後肺部感染髮生率,可安全應用.
목적 탐토신보조화료대진전기위암환자술후폐부감염적영향.방법 안수궤수자표법장2009년1월지2011년1월간재남경군구남경총의원접수치료적139례반유림파결전이적위암병례(배제술전중도폐공능장애자),수궤분위신보조화료조[69례,동정맥결합신보조화료(정맥용약:불뇨밀정、아협산;동맥개입:오사리박、표아매소、의탁박대)1개반료정후접수수술]화직접수술조(70례),비교량조병례술후폐부감염적발생정황.결과 량조병례술전일반정황적비교차이무통계학의의(균P>0.05).소유병례균순리실시D2위암근치수술,술후신보조화료조화직접수술조분별유8례(11.6%)화9례(12.9%)환자출현폐부감염,차이무통계학의의(P>0.05).결론 동정맥결합신보조화료불회증가위암환자술후폐부감염발생솔,가안전응용.
Objective To evaluate the effect of neoadjuvant chemotherapy on the postoperative pulmonary infection of patient with gastric cancer. Methods Between January 2009 and January 2011, 139 patients with curable stage T2N2 or T3N2 gastric cancer were randomly assigned to group 1 (69 cases, neoadjuvant chemotherapy with combined preoperative intraarterial infusion and intravenous chemotherapy before gastrectomy and D2 lymphadenectomy) and group 2 (70 cases, gastrectomy and D2 lymphadenectomy alone). The morbidity of postoperative pneumonia in the two groups were recorded respectively. Results The two groups were similar with respect to various clinical or pathological characteristics. All the patients underwent gastrectomy and D2 lymphadenectomy successfully. Eight patients in group 1 suffered from the postoperative pneumonia, accounting for 11.6%. Nine patients in group 2 suffered from the postoperative pneumonia, accounting for 12.9%. There was no significant difference between the two groups about the incidence of postoperative pneumonia. Conclusion Surgery following neoadjuvant chemotherapy with combined preoperative intraarterial infusion and intravenous chemotherapy is safe with similar morbidity of postoperative pneumonia to immediate surgery in patients with locally-advanced resectable gastric carcinoma.
