国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
14期
1677-1680
,共4页
绝经后子宫内膜%绝经后子宫内膜息肉%绝经后子宫内膜癌%免疫组织化学%Ki-67%ER%PR
絕經後子宮內膜%絕經後子宮內膜息肉%絕經後子宮內膜癌%免疫組織化學%Ki-67%ER%PR
절경후자궁내막%절경후자궁내막식육%절경후자궁내막암%면역조직화학%Ki-67%ER%PR
Postmenopausal endometrium%Postmenopausal endometrial polyps%Postmenopausal endometrial carcinoma%ER%PR%Ki-67
目的 探讨绝经后子宫内膜息肉的发病机制及与子宫内膜癌的关系.方法 选取我院1998年至2006年手术切取的绝经后子宫内膜标本97例,其中绝经后萎缩的子宫内膜35例,绝经后子宫内膜息肉30例,绝经后子宫内膜癌32例.采用免疫组化法,检测ER、PR、Ki-67在组织中的表达情况.结果 绝经后子宫内膜息肉组ER、PR的表达明显高于萎缩子宫内膜及子宫内膜癌组(P<0.05).Ki-67在绝经后萎缩子宫内膜、子宫内膜息肉、子宫内膜癌中的表达逐渐增强(P<0.05).结论 (1)雌、孕激素受体含量升高是绝经后子宫内膜息肉发生的主要原因.(2)绝经后子宫内膜息肉巾Ki-67的高表达可预测息肉可能发展为癌.
目的 探討絕經後子宮內膜息肉的髮病機製及與子宮內膜癌的關繫.方法 選取我院1998年至2006年手術切取的絕經後子宮內膜標本97例,其中絕經後萎縮的子宮內膜35例,絕經後子宮內膜息肉30例,絕經後子宮內膜癌32例.採用免疫組化法,檢測ER、PR、Ki-67在組織中的錶達情況.結果 絕經後子宮內膜息肉組ER、PR的錶達明顯高于萎縮子宮內膜及子宮內膜癌組(P<0.05).Ki-67在絕經後萎縮子宮內膜、子宮內膜息肉、子宮內膜癌中的錶達逐漸增彊(P<0.05).結論 (1)雌、孕激素受體含量升高是絕經後子宮內膜息肉髮生的主要原因.(2)絕經後子宮內膜息肉巾Ki-67的高錶達可預測息肉可能髮展為癌.
목적 탐토절경후자궁내막식육적발병궤제급여자궁내막암적관계.방법 선취아원1998년지2006년수술절취적절경후자궁내막표본97례,기중절경후위축적자궁내막35례,절경후자궁내막식육30례,절경후자궁내막암32례.채용면역조화법,검측ER、PR、Ki-67재조직중적표체정황.결과 절경후자궁내막식육조ER、PR적표체명현고우위축자궁내막급자궁내막암조(P<0.05).Ki-67재절경후위축자궁내막、자궁내막식육、자궁내막암중적표체축점증강(P<0.05).결론 (1)자、잉격소수체함량승고시절경후자궁내막식육발생적주요원인.(2)절경후자궁내막식육건Ki-67적고표체가예측식육가능발전위암.
Objective To explore the relationship between endometrial polyps and endometrial carcinoma in postmenopausal woman.Methods 35 samples of atrophic endometrial tissues,30 of endometrial polyps,and 32 of endometrial carcinoma were collected.The expressions of ER,PR,and Ki-67 were detected by immunohistochemical assay.Results The expressions of ER and PR were significantly higher in the polyps tissues than in the atrophic endometrial tissues and the cancerous tissues (P<0.05).Ki-67 expression increased gradually in the three different types of tissues (P<0.05).Conclusions An elevation in ER and PR plays a major role in the development of postmenopause-induced endometrial polyps.The overexpression of Ki-67 in endometrial polyps may predict of carcinogenesis from polyps.
