CAJ | 학술논문

分化型甲状腺癌(DTC)细胞在进展过程中可发生失分化,以致于术后~(131)I治疗或甲状腺素替代疗效差或无效,成为目前DTC治疗的难题之一.维甲酸作为维生素A的生物活性代谢产物,在调控细胞生长、分化、凋亡等生命活动中起着重要的作用.研究表明,维甲酸能够诱导失分化的DTC细胞再分化,提高肿瘤组织对~(131)I的摄取能力,从而提高DTC治疗的疗效.
분화형갑상선암(DTC)세포재진전과정중가발생실분화,이치우술후~(131)I치료혹갑상선소체대료효차혹무효,성위목전DTC치료적난제지일.유갑산작위유생소A적생물활성대사산물,재조공세포생장、분화、조망등생명활동중기착중요적작용.연구표명,유갑산능구유도실분화적DTC세포재분화,제고종류조직대~(131)I적섭취능력,종이제고DTC치료적료효.
Differentiated thyroid carcinoma(DTC) can occur dedifferentiation in the progress of the process, which results in poor or no effect of the radioiodine therapy and the thyroid hormone replacement therapy after operation. It became one of the most thorny problem for the treatement of DTC now. Retinoic acids, the biologicallyactive metabolite of vitamin A, is of central importance for growth, differentiation, apoptosis and others vital movement of cells. It is demonstrated by studies that retinoic acids-induced redifferentiaon could raise the competence of tumor ingest ~(131)I, accordingly raise effect of the DTC treatment.