CAJ | 학술논문

目的验证肝脏瞬时弹性超声在评估自身免疫性肝炎(AIH)患者肝纤维化程度中的价值.方法用瞬时弹性超声对30例AIH患者进行肝脏瞬时弹性测定,并将测定值与按照Scheuer系统进行纤维化分级的患者肝活组织检查结果作纤维化程度的比较,用Spearman等级相关系数方法进行统计学分析.结果 30例AIH患者中S0期4例,S1期6例,S2期5例,S3期11例,S4期4例.除l例患者因肥胖导致瞬时弹性超声检测失败以外,其余均顺利受检.29例患者测定的瞬时弹性超声硬度值与其肝纤维化分期有显著相关性(r= 0.801,P＜0.01).将S0、S1、S2期合并与S3、S4期合并后对两组间瞬时弹性超声硬度值作比较,t= -3.937,P=0.001,差异有统计学意义.结论肝脏瞬时弹性超声评估AIH患者肝纤维化程度的可靠性较好,并且由于其无创性而在此类患者的长期随访与疗效评估中有着较好的应用前景.
목적 험증간장순시탄성초성재평고자신면역성간염(AIH)환자간섬유화정도중적개치.방법 용순시탄성초성대30례AIH환자진행간장순시탄성측정,병장측정치여안조Scheuer계통진행섬유화분급적환자간활조직검사결과작섬유화정도적비교,용Spearman등급상관계수방법진행통계학분석.결과 30례AIH환자중S0기4례,S1기6례,S2기5례,S3기11례,S4기4례.제l례환자인비반도치순시탄성초성검측실패이외,기여균순리수검.29례환자측정적순시탄성초성경도치여기간섬유화분기유현저상관성(r= 0.801,P＜0.01).장S0、S1、S2기합병여S3、S4기합병후대량조간순시탄성초성경도치작비교,t= -3.937,P=0.001,차이유통계학의의.결론 간장순시탄성초성평고AIH환자간섬유화정도적가고성교호,병차유우기무창성이재차류환자적장기수방여료효평고중유착교호적응용전경.
Objective To validate transient elastography (Fibroscan) in assessment of hepatic fibrosis in autoimmune hepatitis (AIH).Methods Liver stiffness was assessed using Fibroscan in totally 30 patients with AIH.We compared the results of Fibroscan with the Scheuer fibrosis stage in liver biopsy in each patient.Results 4 patients were shown as liver fibrosis stage S0,6 as S 1,5 as S2,11 as S3 and 4 as S4.Failure of the Fibroscan measurement occurred in 1 case (3.3％) because of her increased body mass index (BMI).The stiffness of Fibros can was significantly correlated with the liver biopsy fibrosis stage (r= 0.801,P＜0.001).The liver stiffnesses between mild and moderate fibrosis (S0-2) and advanced fibrosis (S3-4) were significantly different (t=-3.937,P= 0.001).Conclusion Transient elastography (Fibroscan) is a promising non-invasive method for detection of fibrosis in patients with autoimmune hepatitis.Its use for the follow up and management of these patients and should be evaluated further.