CAJ | 학술논문

目的初步研究胃肠道间质瘤切除术后复发的危险因素.方法回顾性分析铜陵市人民医院胃肠外科2005年12月-2010年12月行手术治疗的61例胃肠道间质瘤患者的临床、病理及随访资料,采用Logistic逐步回归模型计算患者术后复发的危险因素.结果共61例患者纳入研究,行胃大部切除或全胃切除术40例,小肠部分切除术7例,结肠部分切除3例,Dixon术2例,肿瘤摘除术9例.15例患者术后给予甲磺酸伊马替尼治疗.术后4例患者失访,57例随访时间均超过1年,术后复发率为12.3％.Logistic逐步回归模型证实肿瘤恶性风险程度是最终危险因素(P=0.021).结论胃肠道间质瘤恶性风险程度是评估术后复发的重要指标.恶性风险程度评分较高的患者,术后给予甲磺酸伊马替尼治疗可能改善患者的短期预后.
목적 초보연구위장도간질류절제술후복발적위험인소.방법 회고성분석동릉시인민의원위장외과2005년12월-2010년12월행수술치료적61례위장도간질류환자적림상、병리급수방자료,채용Logistic축보회귀모형계산환자술후복발적위험인소.결과 공61례환자납입연구,행위대부절제혹전위절제술40례,소장부분절제술7례,결장부분절제3례,Dixon술2례,종류적제술9례.15례환자술후급여갑광산이마체니치료.술후4례환자실방,57례수방시간균초과1년,술후복발솔위12.3％.Logistic축보회귀모형증실종류악성풍험정도시최종위험인소(P=0.021).결론 위장도간질류악성풍험정도시평고술후복발적중요지표.악성풍험정도평분교고적환자,술후급여갑광산이마체니치료가능개선환자적단기예후.
Objective To investigate the postoperative risk factors for gastrointestinal stromal tumors.Methods From December 2005 to December 2010,sixty-one gastrointestinal stromal tumors patients of People' s Hospital of Tongling city gastrointestinal surgery department were analyzed retrospectively.Using the logistic regression model to calculate the postoperative recurrence risk factors. Results Sixty-one patients underwent operation,including gastrectomy (40 cases ),partial intestina parva resection (7 cases),partial colon resection ( 3 cases ),Dixon' s operation ( 2 cases ) and tumorectomy ( 9 cases ).Fifteen patients were given postoperative imatinib Mesylate Capsules (Glivec) treatment.Fifty-seven patients were followed-up more than 1 year and 7 cases were found palindromia ( 12％ ).Logistic model shows that the malignant degree of gastrointestinal stromal tumors is the only risk factor of postoperative palindromia.Conclusions Malignant degree of gastrointestinal stromal tumors is the main risk factor for postoperative palindromia.Imatinib mesylate capsules treatment may be beneficial to the greater stage patients.