CAJ | 학술논문

目的分析急诊科428例抗菌药品不良反应/事件(ADR/ADE)报告的相关因素，了解抗生素ADR/ADE发生特点及规律，为临床护理安全、有效、合理用药提供参考。方法对我院急诊科2007年1月至2010年12月收集到的428例抗生素ADR/ADE报告数据进行回顾性统计分析。结果 428例抗菌药品ADR/ADE报告中，女性多于男性，＜15岁患儿占14.26％，＞50岁患者占61.68％；头孢菌素类居首位占55.85％；静脉点滴占89.96％；主要临床表现为皮肤及其附件、消化系统、全身性损害等。结论加强抗生素ADR/ADE监测及护理工作，减少或者避免ADR/ADE的发生，确保临床护理安全、有效、合理用药。
목적 분석급진과428례항균약품불량반응/사건(ADR/ADE)보고적상관인소，료해항생소ADR/ADE발생특점급규률，위림상호리안전、유효、합리용약제공삼고。방법 대아원급진과2007년1월지2010년12월수집도적428례항생소ADR/ADE보고수거진행회고성통계분석。결과 428례항균약품ADR/ADE보고중，녀성다우남성，＜15세환인점14.26％，＞50세환자점61.68％；두포균소류거수위점55.85％；정맥점적점89.96％；주요림상표현위피부급기부건、소화계통、전신성손해등。결론 가강항생소ADR/ADE감측급호리공작，감소혹자피면ADR/ADE적발생，학보림상호리안전、유효、합리용약。
Objective To learn the adverse drug reactions/events (ADR/ADE) occurred in the characteristics and rules for clinical safe, effective and rational use of available information by analysis of 428antibacterial agents ADR/ADE Reports. Methods 428 antibacterial agents ADR/ADE Reports were statistical analyzed from Jan 1. 2007 to Dec 31. 2010 in our hospital. Results 428 cases of antibacterial agents ADR/ADE, females was slightly more than males; patients between 50 to 83 years old age were accounted for the majority (264 cases,61.68％ ) ;the cases that caused by cephalosporins were accounted for the most(239 case,55.85％ ),385 case that administered intravenously were accounted for the majority (89. 96％ ); antibacterial agents ADR/ADE main clinical manifestations of anaphylactic shock, respiratory, systemic and central nervous system damage. Condusions Strengthening antibacterial agents ADR/ADE monitoring, to decrease the occurrence of Serious ADR/ADE and ensure clinical safety, effective, rational use of drug.