中华烧伤杂志
中華燒傷雜誌
중화소상잡지
16
2012年
3期
170-172
,共3页
丁羚涛%朱宇刚%顾在秋%蔡良良%彭京梁%吕国忠
丁羚濤%硃宇剛%顧在鞦%蔡良良%彭京樑%呂國忠
정령도%주우강%고재추%채량량%팽경량%려국충
烧伤%心肌%肌钙蛋白%肌酸激酶,MB型%心钠素%丹参%川芎嗪
燒傷%心肌%肌鈣蛋白%肌痠激酶,MB型%心鈉素%丹參%川芎嗪
소상%심기%기개단백%기산격매,MB형%심납소%단삼%천궁진
Burns%Myocardium%Troponin%Creatine kinase,MB form%Atrial natriuretic factor%Salvia mihiorrhiza%Tetramethylpyrazine
目的 观察丹参川芎嗪注射液对重度烧伤患者早期心肌损害的影响. 方法 将2010年1月-2011年8月笔者单位收治的20例烧伤总面积大于或等于50％ TBSA的患者按照住院先后顺序编号并分为2组,单数号进入治疗组、双数号进入对照组,每组10例.对照组患者入院后进行常规治疗,包括采用第三军医大学公式补液复苏、抗感染、支持治疗、器官保护治疗等.治疗组在对照组治疗基础上将10 mL丹参川芎嗪注射液加入250 mL葡萄糖注射液(50 g/L)中进行静脉滴注,每日1次、连用3d.于伤后12、24、48、72 h分别抽取2组患者静脉血,测定各时相点血浆中心肌肌钙蛋白I(cTnI)、心肌型肌酸激酶同工酶(CK-MB)以及心钠素水平.对数据进行t检验. 结果 治疗组患者各时相点cTnI、CK-MB、心钠素检测值均低于对照组,2组比较,大部分时相点差异有统计学意义,t值为2.136 ～2.918,P＜0.05或P＜0.01.伤后12h,2组患者上述指标水平均处于峰值,治疗组分别为(28±10) ng/mL、(76±13) U/L、( 430±87) pg/mL,对照组分别为(38±11)ng/mL、(87±10) U/L、(453±91) pg/mL.伤后24 ～ 72 h,2组患者上述指标水平均逐渐下降. 结论 重度烧伤后早期应用丹参川芎嗪注射液,可以有效减轻患者心肌细胞损害,起到保护心肌的作用.
目的 觀察丹參川芎嗪註射液對重度燒傷患者早期心肌損害的影響. 方法 將2010年1月-2011年8月筆者單位收治的20例燒傷總麵積大于或等于50％ TBSA的患者按照住院先後順序編號併分為2組,單數號進入治療組、雙數號進入對照組,每組10例.對照組患者入院後進行常規治療,包括採用第三軍醫大學公式補液複囌、抗感染、支持治療、器官保護治療等.治療組在對照組治療基礎上將10 mL丹參川芎嗪註射液加入250 mL葡萄糖註射液(50 g/L)中進行靜脈滴註,每日1次、連用3d.于傷後12、24、48、72 h分彆抽取2組患者靜脈血,測定各時相點血漿中心肌肌鈣蛋白I(cTnI)、心肌型肌痠激酶同工酶(CK-MB)以及心鈉素水平.對數據進行t檢驗. 結果 治療組患者各時相點cTnI、CK-MB、心鈉素檢測值均低于對照組,2組比較,大部分時相點差異有統計學意義,t值為2.136 ～2.918,P＜0.05或P＜0.01.傷後12h,2組患者上述指標水平均處于峰值,治療組分彆為(28±10) ng/mL、(76±13) U/L、( 430±87) pg/mL,對照組分彆為(38±11)ng/mL、(87±10) U/L、(453±91) pg/mL.傷後24 ～ 72 h,2組患者上述指標水平均逐漸下降. 結論 重度燒傷後早期應用丹參川芎嗪註射液,可以有效減輕患者心肌細胞損害,起到保護心肌的作用.
목적 관찰단삼천궁진주사액대중도소상환자조기심기손해적영향. 방법 장2010년1월-2011년8월필자단위수치적20례소상총면적대우혹등우50％ TBSA적환자안조주원선후순서편호병분위2조,단수호진입치료조、쌍수호진입대조조,매조10례.대조조환자입원후진행상규치료,포괄채용제삼군의대학공식보액복소、항감염、지지치료、기관보호치료등.치료조재대조조치료기출상장10 mL단삼천궁진주사액가입250 mL포도당주사액(50 g/L)중진행정맥적주,매일1차、련용3d.우상후12、24、48、72 h분별추취2조환자정맥혈,측정각시상점혈장중심기기개단백I(cTnI)、심기형기산격매동공매(CK-MB)이급심납소수평.대수거진행t검험. 결과 치료조환자각시상점cTnI、CK-MB、심납소검측치균저우대조조,2조비교,대부분시상점차이유통계학의의,t치위2.136 ～2.918,P＜0.05혹P＜0.01.상후12h,2조환자상술지표수평균처우봉치,치료조분별위(28±10) ng/mL、(76±13) U/L、( 430±87) pg/mL,대조조분별위(38±11)ng/mL、(87±10) U/L、(453±91) pg/mL.상후24 ～ 72 h,2조환자상술지표수평균축점하강. 결론 중도소상후조기응용단삼천궁진주사액,가이유효감경환자심기세포손해,기도보호심기적작용.
Objective To observe the effect of salvia mihiorrhiza and ligustrazine injection on the early myocardial damage of severely burned patients. Methods Twenty severely burned patients hospitalized from January 2010 to August 2011,with burn area equal to or more than 50％ TBSA,were divided into two groups following hospitalization sequence,with odd number patients entering treatment group (T,n =10) and even number patients entering control group (C,n =10).Patients in C group were treated with routine methods,including fluid resuscitation based on the Third Military Medical University formula,antiinfection treatment,support treatment,and organ-protection treatment,etc. In addition to routine treatment methods,patients in T group received intravenous infusion of 250 mL glucose injection (50 g/L) containing 10 mL salvia miltiorrhiza and ligustrazine concoction,once a day,and continued for three days.Venous blood of patients was drawn at post burn hour (PBH) 12,24,48,and 72 to determine the plasma levels of cardiac troponin Ⅰ (cTnI),creatine kinase isozyme MB (CK-MB),and atrial natriuretic peptide (ANP).Data were processed with t test. Results At each time point,levels of cTnI,CK-MB,and ANP were lower in T group than in C group.Differences in contents of these parameters between two groups were statistically significant at most time points,with t values from 2.136 to 2.918,P ＜ 0.05 or P ＜ 0.01.Plasma levels of cTnI,CK-MB,and ANP in both groups peaked at PBH 12,which were respectively (28 ± 10) ng/mL,(76 ± 13) U/L,(430 ±87) pg/mL in T group,and (38 ± 11) ng/mL,(87 ± 10) U/L,(453 ±91) pg/mL in C group. From PBH 24 to 72,contents of above-mentioned parameters decreased gradually in both groups. Conclusions Early use of salvia miltiorrhiza and ligustrazine injection in severely burned patients can effectively reduce myocardial damage,thus protect the myocardium from injury.
