CAJ | 학술논문

目的探讨术前血浆N-末端脑钠肽前体(NT-proBNP)浓度与瓣膜置换同期射频消融术后心房颤动复发的关系.方法 58例心脏瓣膜病合并心房颤动患者,行瓣膜置换同期射频消融术,根据患者术后3个月内心房颤动是否复发将患者分为心房颤动复发组(18例)和心房颤动未复发组(40例),两组患者分别于术前1d和术后9d采用放射免疫法检测血浆NT-proBNP浓度.结果心房颤动复发组术前ld血浆NT-proBNP浓度(中位数为2061.30 ng/L)明显高于心房颤动未复发组(中位数为579.00 ng/L) (P＜ 0.01)；心房颤动复发组术后9d血浆NT-proBNP浓度(中位数为996.60 ng/L)显著高于心房颤动未复发组(中位数为209.20 ng/L)(P＜0.01)；且两组患者术前ld血浆NT-proBNP浓度均高于术后9 d(P＜0.01).结论术前血浆NT-proBNP浓度与瓣膜置换同期射频消融术后心房颤动的复发有一定的关系,对预测心房颤动的复发具有一定的临床应用价值.
목적 탐토술전혈장N-말단뇌납태전체(NT-proBNP)농도여판막치환동기사빈소융술후심방전동복발적관계.방법 58례심장판막병합병심방전동환자,행판막치환동기사빈소융술,근거환자술후3개월내심방전동시부복발장환자분위심방전동복발조(18례)화심방전동미복발조(40례),량조환자분별우술전1d화술후9d채용방사면역법검측혈장NT-proBNP농도.결과 심방전동복발조술전ld혈장NT-proBNP농도(중위수위2061.30 ng/L)명현고우심방전동미복발조(중위수위579.00 ng/L) (P＜ 0.01)；심방전동복발조술후9d혈장NT-proBNP농도(중위수위996.60 ng/L)현저고우심방전동미복발조(중위수위209.20 ng/L)(P＜0.01)；차량조환자술전ld혈장NT-proBNP농도균고우술후9 d(P＜0.01).결론 술전혈장NT-proBNP농도여판막치환동기사빈소융술후심방전동적복발유일정적관계,대예측심방전동적복발구유일정적림상응용개치.
Objective To explore the relationship between preoperative plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and recurrence of atrial fibrillation (AF) after cardiac valve replacement (CVR) combined with radiofrequency ablation.Methods Fifty-eight patients with AF undergoing CVR combined with radiofrequency modified Maze procedure were enrolled in this study.The patients were allocated to either AF recurrence group (AF group,18 cases) or AF no recurrence group (SR group,40 cases) according to whether patient's AF recurrence or not within 3 months after surgery.NT-proBNP were respectively measured in two groups in 1st day before operation and 9th day after operation by radioimmunoassay.Results All the 58 patients were involved in the final analysis.NT-proBNP levels in 1st day before operation and 9th day after operation in AF group was significantly higher than that in SR group (2061.30 ng/L vs.579.00 ng/L,996.60 ng/L vs.209.20 ng/L,P＜ 0.01 ).NT-proBNP levels in 1st day before operation in two groups was significantly higher than that in 9th day after operation (P ＜ 0.01 ).Conclusions There is a good relationship between preoperative plasma NT-proBNP levels and recurrence of AF.It has a clinical value in predicting of recurrence AF after CVR combined with radiofrequency modified Maze procedure.