CAJ | 학술논문

目的探讨罗格列酮(RSG)对2型糖尿病(T2DM)大鼠合并脂肪肝的治疗作用.方法建立T2DM合并脂肪肝的大鼠模型,以RSG进行干预治疗.18周末留取肝组织及血清,检测比较各组血糖、血脂、胰岛素、谷丙转氨酶、TNF-α、瘦素等指标及肝脏病理变化和TNF-α在肝脏的表达.结果 RSG治疗组大鼠肝脏结构较糖尿病对照组明显好转,TNF-α在肝脏的表达水平降低(P<0.05),TG、TC、瘦素水平均明显下降(P<0.05,P<0.01,P<0.05).结论 RSG对实验性糖尿病大鼠合并脂肪肝具有一定的治疗作用.
목적 탐토라격렬동(RSG)대2형당뇨병(T2DM)대서합병지방간적치료작용.방법 건립T2DM합병지방간적대서모형,이RSG진행간예치료.18주말류취간조직급혈청,검측비교각조혈당、혈지、이도소、곡병전안매、TNF-α、수소등지표급간장병리변화화TNF-α재간장적표체.결과 RSG치료조대서간장결구교당뇨병대조조명현호전,TNF-α재간장적표체수평강저(P<0.05),TG、TC、수소수평균명현하강(P<0.05,P<0.01,P<0.05).결론 RSG대실험성당뇨병대서합병지방간구유일정적치료작용.
Objective To investigate the effects of rosiglitazone on fatty liver induced by high-glucose/high-fat diet.Methods T2DM rat model with fatty liver was established by STZ injection and high fat/high glucose diet.Three groups of female SD rats included normal control(NC,n=10),models with(DM-R,n=15) and without(DM-C,n=15)rosiglitazone treatment for 18 weeks.The liver specimens were prepared for H.E.staining,Suda IV-staining and immunohischemistry stain.The levels of fasting serum glucose,insulin,ALT,TNF-α and leptin and the expression of TNF-α in the liver were measured.Results Light and electron microscopy showed that liver tissue panlobular microvascular and macrovascular steatosis and occasional foci of inflammation were improved obviously by rosiglitazone treatment.Rosiglitazone could significantly reduce levels of TG,TC(P<0.05,P<0.01),improve the state of the insulin resistance and reduce the expressive levels of TNF-α and leptin in the liver(P<0.01,P<0.01,P<0.05).Conclusions Rosiglitazone can efficiently treat the fatty liver in the rat model of type 2 diabetes mellitus with fatty liver