中国医学影像技术
中國醫學影像技術
중국의학영상기술
CHINESE JOURNAL OF MEDICAL IMAGING TECHNOLOGY
2009年
7期
1279-1282
,共4页
段钰%于丽娟%韩波%贾承晔%王欣
段鈺%于麗娟%韓波%賈承曄%王訢
단옥%우려연%한파%가승엽%왕흔
肺肿瘤%氟脱氧葡萄糖 F18%标准化摄取值%肿瘤分子生物学指标%体层摄影术,发射型计算机
肺腫瘤%氟脫氧葡萄糖 F18%標準化攝取值%腫瘤分子生物學指標%體層攝影術,髮射型計算機
폐종류%불탈양포도당 F18%표준화섭취치%종류분자생물학지표%체층섭영술,발사형계산궤
Lung neoplasms%Fluorodeoxyglucose F18%Standard uptake value%Tumoral molecular-biological index%Tomography,emission-computed
目的 分析非小细胞肺癌18F-FDG 标准化摄取值(SUV)与GLUT1、Ki-67、MVD、survivin及cyclinA表达的相关性.方法 收集经18F-FDG PET/CT检查且手术切除的非小细胞肺癌33例,采用SP免疫组织化学方法分别检测GLUT1、Ki-67、MVD、survivin及cyclinA,探讨其与SUV的相关性及GLUT1与Ki-67、MVD、survivin及cyclinA 的相关性;分别将病灶按大小(以瘤体3 cm为界)、有无纵隔及肺门淋巴结转移、肺癌的组织学类型分为两组,分别比较两组病灶的GLUT1、Ki-67、MVD、survivin及cyclinA的表达差异是否有统计学意义.结果 33例NSCLC 标本中GLUT1阳性率为66.67%;Ki-67阳性率为72.73%;CD34阳性率为100%.标本平均微血管计数为(12.6±2.9)条,实际范围为12～56条;survivin阳性率为84.85%; cyclinA阳性率为27.27%.结论 FDG SUV与GLUT1呈线性回归关系,与MVD、Ki-67、survivin及cyclinA无相关性. GLUT1、Ki-67、MVD、survivin及cyclinA的表达与病灶大小及有无淋巴结转移无相关性;GLUT1和Ki-67的表达与肺癌的组织学类型有相关性,MVD、survivin及cyclinA的表达与肺癌的组织学类型无相关性.
目的 分析非小細胞肺癌18F-FDG 標準化攝取值(SUV)與GLUT1、Ki-67、MVD、survivin及cyclinA錶達的相關性.方法 收集經18F-FDG PET/CT檢查且手術切除的非小細胞肺癌33例,採用SP免疫組織化學方法分彆檢測GLUT1、Ki-67、MVD、survivin及cyclinA,探討其與SUV的相關性及GLUT1與Ki-67、MVD、survivin及cyclinA 的相關性;分彆將病竈按大小(以瘤體3 cm為界)、有無縱隔及肺門淋巴結轉移、肺癌的組織學類型分為兩組,分彆比較兩組病竈的GLUT1、Ki-67、MVD、survivin及cyclinA的錶達差異是否有統計學意義.結果 33例NSCLC 標本中GLUT1暘性率為66.67%;Ki-67暘性率為72.73%;CD34暘性率為100%.標本平均微血管計數為(12.6±2.9)條,實際範圍為12～56條;survivin暘性率為84.85%; cyclinA暘性率為27.27%.結論 FDG SUV與GLUT1呈線性迴歸關繫,與MVD、Ki-67、survivin及cyclinA無相關性. GLUT1、Ki-67、MVD、survivin及cyclinA的錶達與病竈大小及有無淋巴結轉移無相關性;GLUT1和Ki-67的錶達與肺癌的組織學類型有相關性,MVD、survivin及cyclinA的錶達與肺癌的組織學類型無相關性.
목적 분석비소세포폐암18F-FDG 표준화섭취치(SUV)여GLUT1、Ki-67、MVD、survivin급cyclinA표체적상관성.방법 수집경18F-FDG PET/CT검사차수술절제적비소세포폐암33례,채용SP면역조직화학방법분별검측GLUT1、Ki-67、MVD、survivin급cyclinA,탐토기여SUV적상관성급GLUT1여Ki-67、MVD、survivin급cyclinA 적상관성;분별장병조안대소(이류체3 cm위계)、유무종격급폐문림파결전이、폐암적조직학류형분위량조,분별비교량조병조적GLUT1、Ki-67、MVD、survivin급cyclinA적표체차이시부유통계학의의.결과 33례NSCLC 표본중GLUT1양성솔위66.67%;Ki-67양성솔위72.73%;CD34양성솔위100%.표본평균미혈관계수위(12.6±2.9)조,실제범위위12～56조;survivin양성솔위84.85%; cyclinA양성솔위27.27%.결론 FDG SUV여GLUT1정선성회귀관계,여MVD、Ki-67、survivin급cyclinA무상관성. GLUT1、Ki-67、MVD、survivin급cyclinA적표체여병조대소급유무림파결전이무상관성;GLUT1화Ki-67적표체여폐암적조직학류형유상관성,MVD、survivin급cyclinA적표체여폐암적조직학류형무상관성.
Objective To analyze the correlation between 18F-FDG SUV and immunohistochemical index including GLUT1, Ki-67, MVD, survivin and cyclinA in non-snall-cell lung cancer. Methods Thirty-three patients with NSCLC underwent preoperative PET/CT examination and surgical operation. All patients were divided into two groups according to the size of tumor (cutoff=3 cm), metastasis of mediastinal or hilar lymph nodes or not, and histological types of the cancer, respectively. The expression of GLUT1, Ki-67, MVD, survivin and cyclinA were estimated with SP immunohistochemical technique, and were analyzed statistically to reveal the correlation to FDG SUV. Results The rate of positive expression of GLUT1, Ki-67 and CD34 were 66.67%, 72.73% and 100%, respectively. The mean value of CD34 in all 33 patients was 12.6±2.9 (12-56). The rate of positive expression of survivin was 84.85%, and the corresponding data of cyclinA was 27.27%. Conclusion There is linear correlation between FDG PET SUV and GLUT1, but not between FDG PET SUV and Ki-67, MVD, survivin and cyclinA. The expressions of GLUT1, Ki-67, MVD, survivin and cyclinA are not related with the size of tumor, nor metastasis of lymph nodes. The expression of GLUT1 and Ki-67 is related with histological types of the cancer, but not with MVD, survivin and cyclinA.
