CAJ | 학술논문

目的研究胆囊幽门螺杆菌感染与胆囊胆固醇结石形成的关系.方法我院2002年6月至2004年1月肝胆外科腹腔镜胆囊切除术60例,采用对照研究方法,对35例单纯胆囊结石患者(实验组)及25例单纯胆囊息肉患者(对照组)的胃幽门螺杆菌进行检测,采用PCR方法检测2组患者的胆汁及结石幽门螺杆菌细胞毒素相关基因抗原(CagA).结果实验组胃幽门螺杆菌感染率为51.43%(18/35),对照组为48.00%(12/25),2组患者胃幽门螺杆菌感染率差异无统计学意义(χ~2=0.079,P>0.05).实验组胆汁标本中CagA 7例阳性(20.00%),结石标本中1例阳性(2.86%),对照组胆汁标本无一例阳性,2组胆汁CagA检出率差异有统计学意义(χ~2=5.822,P<0.05).结论幽门螺杆菌DNA存在于胆囊胆固醇结石患者的胆汁及结石中,与胃幽门螺杆菌感染有关,胆囊幽门螺杆菌感染与胆囊胆固醇结石形成有关.
목적 연구담낭유문라간균감염여담낭담고순결석형성적관계.방법 아원2002년6월지2004년1월간담외과복강경담낭절제술60례,채용대조연구방법,대35례단순담낭결석환자(실험조)급25례단순담낭식육환자(대조조)적위유문라간균진행검측,채용PCR방법검측2조환자적담즙급결석유문라간균세포독소상관기인항원(CagA).결과 실험조위유문라간균감염솔위51.43%(18/35),대조조위48.00%(12/25),2조환자위유문라간균감염솔차이무통계학의의(χ~2=0.079,P>0.05).실험조담즙표본중CagA 7례양성(20.00%),결석표본중1례양성(2.86%),대조조담즙표본무일례양성,2조담즙CagA검출솔차이유통계학의의(χ~2=5.822,P<0.05).결론 유문라간균DNA존재우담낭담고순결석환자적담즙급결석중,여위유문라간균감염유관,담낭유문라간균감염여담낭담고순결석형성유관.
Objective To study the relationship between Helicobacter pylori(Hp) infection and the development of gallstone.Methods In a cage control study,the infection of Hp in all patients'stomach was tested.There are 35 patients of simple cholelithiasis in the cholelithiasis group (experiment group) and 25 patients of simple cholecyst polyposis in the cholecyst polyposis group (control group).The Helicobacter pylori cytotoxin associated gene antigen (Cag-A) were amplified by PCR in bile and gallstones of two groups.Results There were no difference in the infection rate of Hp between two groups(51.43%(8/35) and 48.00%(12/25),respectively,χ~2=0.079,P>0.05).However,7 of 35 bile (20.00%),1 of 35 gallstones (2.86%) were positive for Hp Cag-A by PCR analysis in the cholelithiasis group,with none of 15 bile were positive in the cholecyst polyposis group.The finding of Cag-A in bile Wag related with Hp colony in stomach.Conclusions Hp is present in some bile and gallstones of cholelithiasis patients,and was related with Hp colony in stomach.There are some correlation between the infection of Hp in gallbladder and the formation of gallstone.