CAJ | 학술논문

肝移植是治疗原发性肝癌的有效手段,但肿瘤复发和转移是影响患者预后的关键因素.肝癌肝移植术后辅助化疗能起到降低肿瘤复发率、提高患者长期生存率的作用.虽然化疗的具体方案及疗效存在争议,但仍作为一种安全町行的方法广泛应用于临床治疗.随着化疗方案的探索及新型药物的开发,肝癌肝移植术后辅助化疗的疗效得到明显提高.
간이식시치료원발성간암적유효수단,단종류복발화전이시영향환자예후적관건인소.간암간이식술후보조화료능기도강저종류복발솔、제고환자장기생존솔적작용.수연화료적구체방안급료효존재쟁의,단잉작위일충안전정행적방법엄범응용우림상치료.수착화료방안적탐색급신형약물적개발,간암간이식술후보조화료적료효득도명현제고.
Liver transplantation may be the best curative treatment for patients with cirrhosis and primary hepatocellular carcinoma. However, tumor recurrence and metastasis is still a difficult problem of liver trans-plantation. Postoperative adjuvant chemotherapy has been employed in an attempt to eliminate micrometasta-ses, and could improve long-term survival after LT for hepatocellular carcinoma. Although the specific chem-otherapy and its efficacy remain controversial, it has been widely used as a safe, feasible and effective meth-od in several clincial institutions.