CAJ | 학술논문

目的观察曲安奈德封闭治疗中出现局部皮肤色素减退的现象,探讨其发生机制及预防措施.方法将疼痛门诊治疗的病人根据镇痛封闭液的不同分为泼尼松龙组和曲安奈德组,比较其治疗后局部皮肤色素减退的发生率.结果泼尼松龙组未发现治疗后出现局部皮肤色素减退,曲安奈德组表浅部位注射后2～3周部分病例出现局部皮肤色素减退,深部注射未出现此现象.色素减退多见于育龄期妇女.结论曲安奈德封闭治疗可能出现局部皮肤色素减退,曲安奈德溢出引起了局部皮肤色素减退,注射后出针时局部按压可减少其发生.临床治疗时应事先告知患者并发色素减退的可能性.
목적 관찰곡안내덕봉폐치료중출현국부피부색소감퇴적현상,탐토기발생궤제급예방조시.방법 장동통문진치료적병인근거진통봉폐액적불동분위발니송룡조화곡안내덕조,비교기치료후국부피부색소감퇴적발생솔.결과 발니송룡조미발현치료후출현국부피부색소감퇴,곡안내덕조표천부위주사후2～3주부분병례출현국부피부색소감퇴,심부주사미출현차현상.색소감퇴다견우육령기부녀.결론 곡안내덕봉폐치료가능출현국부피부색소감퇴,곡안내덕일출인기료국부피부색소감퇴,주사후출침시국부안압가감소기발생.림상치료시응사선고지환자병발색소감퇴적가능성.
Objective To observe the local cutaneous depigmentation after triamcinolone acetonide injection and investigate the mechanism and precaution of depigmentation. Methods Outpatients were divided into prednisolone group and triamcinolone acetonide group according to the injection medicine.The incidence rate of local cutaneous depigmentation was compared. Results Local cutaneous depigmentation was observed among some patients in triamcinolone acetonide group when given at a superfcial site 2-3 weeks after injection. Local skin discoloration was not found in prednisolone group,nor was it when triamcinolone acetonide was injected deeply. Depigmentation mostly happened among women in child-bearing period. Conclusions Treatment with triamcinolone acetonide injection may cause local cutaneous depigmentation, leakage of triamcinolone acetonide resulted in depigmentation and the adverse effects of injection may be prevented by applying pressure over the injection site as the needle is withdrawn to prevent leakage of corticosteroid along the needle track.Patients should have been forewarned about the possibility of depigmentation.