中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
16期
10-11
,共2页
宫内发育迟缓%胰岛素%胰岛素样生长因子-1%脂联素%新生儿
宮內髮育遲緩%胰島素%胰島素樣生長因子-1%脂聯素%新生兒
궁내발육지완%이도소%이도소양생장인자-1%지련소%신생인
Intrauterine growth retardation%Insulin%Insulin-like growth factor-1%Adiponectin%Neonate
目的 探讨宫内发育迟缓(IUGR)的发生与脐血胰岛素(INS)、胰岛素样生长因子-1(IGF-1)和脂联素的关系,研究内分泌环境对胎儿的影响.方法 选择宫内发育迟缓新生儿60例(IUGR组)和正常出生体质量儿30例(对照组),测定并比较两组脐血中INS、IGF-1和脂联素的含量.结果 IUGR组脐血中INS、IGF-1和脂联素的含量均明显低于对照组(t =5.21,5.13,4.99,P＜0.05).相关分析显示出生体质量与脐血中INS、IGF-1和脂联素水平呈正相关(t=0.553,0.612,0.568,P＜0.05).结论 脐血INS、IGF-1和脂联素水平是影响出生体质量的重要因素,它们与胎儿宫内生长发育密切相关,为宫内发育迟缓儿生后的早期发现和早期治疗提供临床指导.
目的 探討宮內髮育遲緩(IUGR)的髮生與臍血胰島素(INS)、胰島素樣生長因子-1(IGF-1)和脂聯素的關繫,研究內分泌環境對胎兒的影響.方法 選擇宮內髮育遲緩新生兒60例(IUGR組)和正常齣生體質量兒30例(對照組),測定併比較兩組臍血中INS、IGF-1和脂聯素的含量.結果 IUGR組臍血中INS、IGF-1和脂聯素的含量均明顯低于對照組(t =5.21,5.13,4.99,P＜0.05).相關分析顯示齣生體質量與臍血中INS、IGF-1和脂聯素水平呈正相關(t=0.553,0.612,0.568,P＜0.05).結論 臍血INS、IGF-1和脂聯素水平是影響齣生體質量的重要因素,它們與胎兒宮內生長髮育密切相關,為宮內髮育遲緩兒生後的早期髮現和早期治療提供臨床指導.
목적 탐토궁내발육지완(IUGR)적발생여제혈이도소(INS)、이도소양생장인자-1(IGF-1)화지련소적관계,연구내분비배경대태인적영향.방법 선택궁내발육지완신생인60례(IUGR조)화정상출생체질량인30례(대조조),측정병비교량조제혈중INS、IGF-1화지련소적함량.결과 IUGR조제혈중INS、IGF-1화지련소적함량균명현저우대조조(t =5.21,5.13,4.99,P＜0.05).상관분석현시출생체질량여제혈중INS、IGF-1화지련소수평정정상관(t=0.553,0.612,0.568,P＜0.05).결론 제혈INS、IGF-1화지련소수평시영향출생체질량적중요인소,타문여태인궁내생장발육밀절상관,위궁내발육지완인생후적조기발현화조기치료제공림상지도.
Objective To investigate the levels of insulin (INS),insulin-like growth factor-1(IGF-1) and adiponectin in the cord blood of neonates with intrauterine growth retardation (IUGR),and assess the effect of the endocrine environment on IUGR.Methods Sixty newborn infants were selected (IUGR group),thirty normal birth weight infants were selected as control group.The levels of INS,IGF-1 and adiponectin in the cord blood were measured.Results Umbilical cord serum levels of INS,IGF-1 and adiponectin in the IUGR group were significantly lower than those in the control group (P ＜0.05 ).Birth weight was positively correlated with umbilical cord serum INS,IGF-1 and adiponectin levels ( P ＜ 0.05).Conclusions The levels of INS,IGF-1 and adiponectin in the cord blood are correlated with fetal weight.They are closely related to human fetal growth.They can provide clincical guidance for early diagnosis and treatment of intrauterine growth retardation(IUGR).
