CAJ | 학술논문

目的:研究MGMT和Survivin在乳腺癌中的表达及其临床意义.方法:福尔马林固定,石蜡包埋乳腺癌和腺瘤标本,采用SABC免疫组织化学方法检测MGMT和Survivin在这些组织中的表达.结果:MGMT和Survivin在乳腺癌和乳腺腺瘤中的表达有显著性差异.MGMT在乳腺癌中的表达与患者的年龄、淋巴结转移有关,而Survivin仅与淋巴结转移有关.另外,MGMT和Survivin之间具有相关性(r=0.48,P<0.01).结论:MGMT和Survivin的异常表达与乳腺癌的淋巴结转移有关;MGMT和Survivin可以作为判断乳腺癌发生和预后的重要指标;检测它们的表达可以指导临床上化疗方案的制定.
목적:연구MGMT화Survivin재유선암중적표체급기림상의의.방법:복이마림고정,석사포매유선암화선류표본,채용SABC면역조직화학방법검측MGMT화Survivin재저사조직중적표체.결과:MGMT화Survivin재유선암화유선선류중적표체유현저성차이.MGMT재유선암중적표체여환자적년령、림파결전이유관,이Survivin부여림파결전이유관.령외,MGMT화Survivin지간구유상관성(r=0.48,P<0.01).결론:MGMT화Survivin적이상표체여유선암적림파결전이유관;MGMT화Survivin가이작위판단유선암발생화예후적중요지표;검측타문적표체가이지도림상상화료방안적제정.
Objective:To investigate the expression of MGMT and Survivin in breast cancer and its clinical significance.Methods:Specimens from breast adenoma and breast cancer were taken and had been Formalin-fixed,paraffin-embedded.With Strept Avidin-Biotin Complex(SABC) immunohistochemical technique,the expression of MGMT and Survivin in these specimens was examined.Results:It was found that there were significant differences between MGMT and Survivin in breast adenoma and breast lymph node metastasis,while the expression of Survivin was associated with lymph node metastasis only.Meanwhile,the expression of MGMT was correlated with that of Survivin(r=0.34,P<0.01).Conclusion:It was concluded that the abnormal expressions of MGMT and Survivin were associated with lymph node metastasis.They possibly could be useful indexes for the primary screening and the prognosis of breast cancer.The examination of them may have an important guiding significance in the chemotherapy strategy.