中国医学影像技术
中國醫學影像技術
중국의학영상기술
CHINESE JOURNAL OF MEDICAL IMAGING TECHNOLOGY
2009年
7期
1152-1155
,共4页
甘景梨%段惠峰%杨家明%高存友%张东卫%祝希泉%史振娟%蒋占魁%王志娟%马誉
甘景梨%段惠峰%楊傢明%高存友%張東衛%祝希泉%史振娟%蔣佔魁%王誌娟%馬譽
감경리%단혜봉%양가명%고존우%장동위%축희천%사진연%장점괴%왕지연%마예
精神分裂症%磁共振波谱%前额叶%丘脑
精神分裂癥%磁共振波譜%前額葉%丘腦
정신분렬증%자공진파보%전액협%구뇌
Schizophrenia%Magnetic resonance spectroscopy%Prefrontal lobe%Thalamus
目的 探讨男性精神分裂症患者前额叶、丘脑的氢质子磁共振波谱(1H-MRS)的特点.方法 以26例7 d内未使用抗精神病药物及影响脑内乙酰胆碱神经递质药物的男性精神分裂症患者为研究组,以28名正常人为对照组.在入组24 h内两组采用多体素1H-MRS检测前额叶和丘脑生化代谢物N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)与肌酸复合物(Cr),完成NAA/Cr值、Cho/Cr值和NAA/(Cho+Cr)值的计算.结果 与对照组相比,研究组左侧前额叶及左、右侧丘脑NAA/Cr值(分别为1.40±0.34、1.45±0.31和1.51±0.32)均低于对照组(分别为1.69±0.31、1.69±0.23和1.70±0.28),差异有统计学意义(P均<0.05).Cho/Cr值和NAA/(Cho+Cr)值两组间比较差异无统计学意义.结论 男性精神分裂症患者的1H-MRS与正常人存在差异,左侧前额叶及丘脑同时存在神经元的功能和(或)结构异常.
目的 探討男性精神分裂癥患者前額葉、丘腦的氫質子磁共振波譜(1H-MRS)的特點.方法 以26例7 d內未使用抗精神病藥物及影響腦內乙酰膽堿神經遞質藥物的男性精神分裂癥患者為研究組,以28名正常人為對照組.在入組24 h內兩組採用多體素1H-MRS檢測前額葉和丘腦生化代謝物N-乙酰基天門鼕氨痠(NAA)、膽堿複閤物(Cho)與肌痠複閤物(Cr),完成NAA/Cr值、Cho/Cr值和NAA/(Cho+Cr)值的計算.結果 與對照組相比,研究組左側前額葉及左、右側丘腦NAA/Cr值(分彆為1.40±0.34、1.45±0.31和1.51±0.32)均低于對照組(分彆為1.69±0.31、1.69±0.23和1.70±0.28),差異有統計學意義(P均<0.05).Cho/Cr值和NAA/(Cho+Cr)值兩組間比較差異無統計學意義.結論 男性精神分裂癥患者的1H-MRS與正常人存在差異,左側前額葉及丘腦同時存在神經元的功能和(或)結構異常.
목적 탐토남성정신분렬증환자전액협、구뇌적경질자자공진파보(1H-MRS)적특점.방법 이26례7 d내미사용항정신병약물급영향뇌내을선담감신경체질약물적남성정신분렬증환자위연구조,이28명정상인위대조조.재입조24 h내량조채용다체소1H-MRS검측전액협화구뇌생화대사물N-을선기천문동안산(NAA)、담감복합물(Cho)여기산복합물(Cr),완성NAA/Cr치、Cho/Cr치화NAA/(Cho+Cr)치적계산.결과 여대조조상비,연구조좌측전액협급좌、우측구뇌NAA/Cr치(분별위1.40±0.34、1.45±0.31화1.51±0.32)균저우대조조(분별위1.69±0.31、1.69±0.23화1.70±0.28),차이유통계학의의(P균<0.05).Cho/Cr치화NAA/(Cho+Cr)치량조간비교차이무통계학의의.결론 남성정신분렬증환자적1H-MRS여정상인존재차이,좌측전액협급구뇌동시존재신경원적공능화(혹)결구이상.
Objective To identify the metabolite levels in prefrontal lobe and thalamus in patients of schizophrenia with proton magnetic resonance spectroscopy (1H-MRS). Methods Twenty-six schizophrenics with medicine-free for at least 7 d and 28 normal controls were assessed in this study. All subjects underwent examination of multi-voxel 1H-MRS on prefrontal lobe and thalamus within 24 h. The NAA, Cho and Cr were measured and the ratios of NAA/Cr, Cho/Cr and NAA/(Cho+Cr) were determined. Results Compared with the controls, the NAA/Cr ratio of schizophrenics was significantly lower in left prefrontal lobe and bilateral thalamus (all P＜0.05). No statistical difference of NAA/(Cho+Cr) ratio and the Cho/Cr ratio was found between two groups. Conclusion Abnormalities in neuronal function and/or integrity are present at left prefrontal lobe and bilateral thalamus simultaneously in schizophrenics.
