CAJ | 학술논문

子宫内膜异位症(内异症)是一种易复发并具有侵袭性的慢性疾病,特点是有生长功能的子宫内膜腺上皮腺体和间质细胞出现在正常子宫体腔内膜以外,可以影响约15%生育年龄的妇女,引起性交痛、盆腔疼痛、痛经和不孕.目前内异症病因不清,已经提出几种假说解释它的发生机制,研究认为遗传因素在内异症的发生发展中起作用,多基因/多因素理论已经被广泛接受.本文对内异症相关基因多态性和基因产物异常表达的研究加以分析,试图从分子遗传学角度解释内异症发生发展的机制.
자궁내막이위증(내이증)시일충역복발병구유침습성적만성질병,특점시유생장공능적자궁내막선상피선체화간질세포출현재정상자궁체강내막이외,가이영향약15%생육년령적부녀,인기성교통、분강동통、통경화불잉.목전내이증병인불청,이경제출궤충가설해석타적발생궤제,연구인위유전인소재내이증적발생발전중기작용,다기인/다인소이론이경피엄범접수.본문대내이증상관기인다태성화기인산물이상표체적연구가이분석,시도종분자유전학각도해석내이증발생발전적궤제.
Endometriosis is a chronic recurrent and progressive disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 15% of women of child-bearing age. It can cause dyspareunia, pelvic pain, dysmenorrhea, and infertility. Although the etiology of endometriosis is unknown, several hypotheses have been proposed to explain its origin. Recently,genetic factors are thought to contribute to the development of this disease, and polygene/multiple factor theory has been accepted generally. This article presents an overview of research advancement of genes related to endometriosis, including gene polymorphism and abnormal expression of gene product. We try to explain the developmental mechanism of endometriosis from the angle of molecular genetics.