国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
21期
1606-1609
,共4页
黄志俭%柯明耀%李艳%谢红旗%赵年贵%昊美女%蔡坚
黃誌儉%柯明耀%李豔%謝紅旂%趙年貴%昊美女%蔡堅
황지검%가명요%리염%사홍기%조년귀%호미녀%채견
弥漫性泛细支气管炎%肺功能%影像学
瀰漫性汎細支氣管炎%肺功能%影像學
미만성범세지기관염%폐공능%영상학
Diffuse panbrochiolitis%Lung function%Radiology
目的 探讨小剂量红霉素对弥漫性泛细支气管炎肺功能及影像学的作用.方法 回顾性分析2008年至2010年入住我院呼吸科9例弥漫性泛细支气管炎患者资料,比较小剂量红霉素治疗3～6个月前后肺功能及其影像学改变的情况.结果 治疗后肺功能检查第1秒用力呼气量(FEV1)占预计值％(81.39％±4.68％ vs 78.27％±4.98％)、用力肺活量(FVC)占预计值％(80.93％±5.46％ vs76.59％±5.57％)、FEV1/FVC(65.34％±3.36％ vs 64.70％±3.43％)、呼出75％肺活量时的用力呼气流速占预计值％(47.54％±5.71％ vs 42.76％±3.79％)较治疗前升高(P＜0.05或P＜0.01),而残气量/肺总量较治疗前显著下降(46.74％±2.87％ vs 49.86％±3.25％)(P＜0.01).结论 小剂量红霉素能有效改善弥漫性泛细支气管炎的肺功能,减轻气流阻塞和气体的陷闭,与此同时能改善与小气道阻塞相关的影像学改变.
目的 探討小劑量紅黴素對瀰漫性汎細支氣管炎肺功能及影像學的作用.方法 迴顧性分析2008年至2010年入住我院呼吸科9例瀰漫性汎細支氣管炎患者資料,比較小劑量紅黴素治療3～6箇月前後肺功能及其影像學改變的情況.結果 治療後肺功能檢查第1秒用力呼氣量(FEV1)佔預計值％(81.39％±4.68％ vs 78.27％±4.98％)、用力肺活量(FVC)佔預計值％(80.93％±5.46％ vs76.59％±5.57％)、FEV1/FVC(65.34％±3.36％ vs 64.70％±3.43％)、呼齣75％肺活量時的用力呼氣流速佔預計值％(47.54％±5.71％ vs 42.76％±3.79％)較治療前升高(P＜0.05或P＜0.01),而殘氣量/肺總量較治療前顯著下降(46.74％±2.87％ vs 49.86％±3.25％)(P＜0.01).結論 小劑量紅黴素能有效改善瀰漫性汎細支氣管炎的肺功能,減輕氣流阻塞和氣體的陷閉,與此同時能改善與小氣道阻塞相關的影像學改變.
목적 탐토소제량홍매소대미만성범세지기관염폐공능급영상학적작용.방법 회고성분석2008년지2010년입주아원호흡과9례미만성범세지기관염환자자료,비교소제량홍매소치료3～6개월전후폐공능급기영상학개변적정황.결과 치료후폐공능검사제1초용력호기량(FEV1)점예계치％(81.39％±4.68％ vs 78.27％±4.98％)、용력폐활량(FVC)점예계치％(80.93％±5.46％ vs76.59％±5.57％)、FEV1/FVC(65.34％±3.36％ vs 64.70％±3.43％)、호출75％폐활량시적용력호기류속점예계치％(47.54％±5.71％ vs 42.76％±3.79％)교치료전승고(P＜0.05혹P＜0.01),이잔기량/폐총량교치료전현저하강(46.74％±2.87％ vs 49.86％±3.25％)(P＜0.01).결론 소제량홍매소능유효개선미만성범세지기관염적폐공능,감경기류조새화기체적함폐,여차동시능개선여소기도조새상관적영상학개변.
Objective To investigate the effect of low-dose erythromythin on lung function and radiology in patients with diffuse panbrochiolitis (DPB).Methods The data of nine patients with DPB hospitalized in respiratory department were collected and analyzed retrospectively.The changes of lung function and radiology after treatment with low-dose erythromythin were compared with pre-treatment.Results Compared with pre-treatment,after therapy,the predicted percentage of forced expiratory volume in one second (FEV1) ( 81.39 ％ ± 4.68 ％ vs 78.27 ％ + 4.98 ％ ),the predicted percentage of forced vital capacity (FVC) ( 80.93 ％± 5.46 ％ vs 76.59 ％ ± 5.57％ ),the ratio of FEV1 to FVC (65.34％±3.36％ vs 64.70％±3.43％) and the predicted percentage of forced expiratory volume with 75％ vital capacity (47.54％±5.71％ vs 42.76％ +3.79％) has been increased ( P ＜0.05).The ratio of residual volume to total lung capacity (46.74 ％±2.87 ％ vs 49.86 ％ + 3.25 ％ ) decreased markedly ( P ＜0.01).Conclusions Low-dose erythromythin can improve the lung function of the patients with DPB efficiently to alleviate the obstruction of small airway and gas trapping,and improve the change of radiology correlated with the small airway obstruction.
