CAJ | 학술논문

CD8+T淋巴细胞的亚群不仅具有细胞毒性作用,还能调节机体的免疫反应.具有免疫抑制作用的CD8+调节性T细胞(Tr)能有效阻断过强的免疫应答,维持机体的免疫稳态.随着医学科学的不断发展,近年来对CD8+Tr的分型、作用机制及其参与调节自体免疫、器官移植耐受、肿瘤免疫和感染免疫应答等方面的研究取得了巨大进展.
CD8+T림파세포적아군불부구유세포독성작용,환능조절궤체적면역반응.구유면역억제작용적CD8+조절성T세포(Tr)능유효조단과강적면역응답,유지궤체적면역은태.수착의학과학적불단발전,근년래대CD8+Tr적분형、작용궤제급기삼여조절자체면역、기관이식내수、종류면역화감염면역응답등방면적연구취득료거대진전.
CD8+ regulatory T lymphocyte (CD8+ Tr) is a specific T subset with cytotoxic activity, whichcould actively regulate immune responses. CD8+ Tr could suppress unsuitable immune responses and keep theimmunological balance of the host. In recent years, a great progress has been made in the study on CD8+ Tr in-cluding their subgroup, functional mechanism, and the immunoregulatory role in autoimmunity, organ trans-plantation, tumor, infection immunity.