中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
4期
533-534
,共2页
阻塞性,睡眠,呼吸暂停%低通气综合征%高血压%Th1/Th2平衡
阻塞性,睡眠,呼吸暫停%低通氣綜閤徵%高血壓%Th1/Th2平衡
조새성,수면,호흡잠정%저통기종합정%고혈압%Th1/Th2평형
目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压(HT)患者Th1/Th2细胞因子变化及其临床意义.方法 选取经多导睡眠监测仪确诊OSAHS合并高血压患者48例(OSAHS+ HT组)、OSAHS患者46例,初诊原发性高血压患者(HT组)共45例,采用酶联免疫吸附测定血浆干扰素γ(IFN-γ)、肿瘤坏死因子β(TNF-β)、白细胞介素4(IL4)、白细胞介素10(IL-10)水平,并分析各细胞因子水平分别与患者平均动脉压的相关性.结果 OSAHS +HT组、0SAHS组、HT组三组Th1细胞因子IFN-γ分别为(45.17±11.87) ng/L、(41.82±10.43) ng/L、(57.94±9.57) ng/L、TNF-β分别为(44.46±21.23) ng/L、(46.26±18.42)ng/L、(56.85±11.57) ng/L,Th2细胞因子IL-4水平分别为(56.13±21.46) ng/L、( 54.78±27.23) ng/L、(53.25±24.41)ng/L,IL-10水平分别为(39.21±6.23) ng/L、(38.26±10.43) ng/L、(35.54±8.96) ng/L.OSAHS+ HT组分别与OSAHS组、HT组的IFN-γ、TNF-β水平差异均有统计学意义(t=15.369,24.598,22.123,19.258,均P＜0.05),而OSAHS组与HT组差异均无统计学意义(t=1.032,2.121,均P＞0.05).IL-4各组间水平差异均无统计学意义(t=1.102,0.489,1.214,均P＞0.05)；OSAHS+ HT组与HT组IL-10水平差异有统计学意义(t=21.236,P＜0.05),OSAHS+ HT组与OSAHS组、OSAHS组与HT组IL-10水平差异均无统计学意义(t =0.985,1.125,均P＞0.05).结论 OSAHS合并HT患者Th1/Th2平衡紊乱失调更加严重,应引起临床注意,进行早期干预.
目的 探討阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)閤併高血壓(HT)患者Th1/Th2細胞因子變化及其臨床意義.方法 選取經多導睡眠鑑測儀確診OSAHS閤併高血壓患者48例(OSAHS+ HT組)、OSAHS患者46例,初診原髮性高血壓患者(HT組)共45例,採用酶聯免疫吸附測定血漿榦擾素γ(IFN-γ)、腫瘤壞死因子β(TNF-β)、白細胞介素4(IL4)、白細胞介素10(IL-10)水平,併分析各細胞因子水平分彆與患者平均動脈壓的相關性.結果 OSAHS +HT組、0SAHS組、HT組三組Th1細胞因子IFN-γ分彆為(45.17±11.87) ng/L、(41.82±10.43) ng/L、(57.94±9.57) ng/L、TNF-β分彆為(44.46±21.23) ng/L、(46.26±18.42)ng/L、(56.85±11.57) ng/L,Th2細胞因子IL-4水平分彆為(56.13±21.46) ng/L、( 54.78±27.23) ng/L、(53.25±24.41)ng/L,IL-10水平分彆為(39.21±6.23) ng/L、(38.26±10.43) ng/L、(35.54±8.96) ng/L.OSAHS+ HT組分彆與OSAHS組、HT組的IFN-γ、TNF-β水平差異均有統計學意義(t=15.369,24.598,22.123,19.258,均P＜0.05),而OSAHS組與HT組差異均無統計學意義(t=1.032,2.121,均P＞0.05).IL-4各組間水平差異均無統計學意義(t=1.102,0.489,1.214,均P＞0.05)；OSAHS+ HT組與HT組IL-10水平差異有統計學意義(t=21.236,P＜0.05),OSAHS+ HT組與OSAHS組、OSAHS組與HT組IL-10水平差異均無統計學意義(t =0.985,1.125,均P＞0.05).結論 OSAHS閤併HT患者Th1/Th2平衡紊亂失調更加嚴重,應引起臨床註意,進行早期榦預.
목적 탐토조새성수면호흡잠정저통기종합정(OSAHS)합병고혈압(HT)환자Th1/Th2세포인자변화급기림상의의.방법 선취경다도수면감측의학진OSAHS합병고혈압환자48례(OSAHS+ HT조)、OSAHS환자46례,초진원발성고혈압환자(HT조)공45례,채용매련면역흡부측정혈장간우소γ(IFN-γ)、종류배사인자β(TNF-β)、백세포개소4(IL4)、백세포개소10(IL-10)수평,병분석각세포인자수평분별여환자평균동맥압적상관성.결과 OSAHS +HT조、0SAHS조、HT조삼조Th1세포인자IFN-γ분별위(45.17±11.87) ng/L、(41.82±10.43) ng/L、(57.94±9.57) ng/L、TNF-β분별위(44.46±21.23) ng/L、(46.26±18.42)ng/L、(56.85±11.57) ng/L,Th2세포인자IL-4수평분별위(56.13±21.46) ng/L、( 54.78±27.23) ng/L、(53.25±24.41)ng/L,IL-10수평분별위(39.21±6.23) ng/L、(38.26±10.43) ng/L、(35.54±8.96) ng/L.OSAHS+ HT조분별여OSAHS조、HT조적IFN-γ、TNF-β수평차이균유통계학의의(t=15.369,24.598,22.123,19.258,균P＜0.05),이OSAHS조여HT조차이균무통계학의의(t=1.032,2.121,균P＞0.05).IL-4각조간수평차이균무통계학의의(t=1.102,0.489,1.214,균P＞0.05)；OSAHS+ HT조여HT조IL-10수평차이유통계학의의(t=21.236,P＜0.05),OSAHS+ HT조여OSAHS조、OSAHS조여HT조IL-10수평차이균무통계학의의(t =0.985,1.125,균P＞0.05).결론 OSAHS합병HT환자Th1/Th2평형문란실조경가엄중,응인기림상주의,진행조기간예.
