CAJ | 학술논문

目的探讨影响原发性肝细胞癌(hepatocelluar carcinoma,HCC)根治性切除术后肝外复发的危险因素.方法回顾性分析行根治性切除的238例HCC患者的临床资料,确定影响术后肝外复发的危险因素.结果本组患者随访7-78个月,随访中位时间为34个月,32例(13.4%)出现肝外复发.依据单因素分析结果,术前血清甲胎蛋白(α fetoprotein,AFP)>1000 ng/ml、天冬氨酸氨基转移酶>50 IU/L、肝静脉侵犯、周围脏器侵犯、子灶、肿瘤包膜缺失是HCC根治性切除术后肝外复发的危险因素.多因素分析显示血清AFP>1000 ng/ml、肝静脉侵犯、周围脏器侵犯是肝外复发的独立危险因素.结论 HCC根治性切除术后肝外复发与术前血清AFP>1000 ng/ml、肝静脉侵犯、周围脏器侵犯有关.对具有这些危险因素的患者术后应加强随访.
목적 탐토영향원발성간세포암(hepatocelluar carcinoma,HCC)근치성절제술후간외복발적위험인소.방법 회고성분석행근치성절제적238례HCC환자적림상자료,학정영향술후간외복발적위험인소.결과 본조환자수방7-78개월,수방중위시간위34개월,32례(13.4%)출현간외복발.의거단인소분석결과,술전혈청갑태단백(α fetoprotein,AFP)>1000 ng/ml、천동안산안기전이매>50 IU/L、간정맥침범、주위장기침범、자조、종류포막결실시HCC근치성절제술후간외복발적위험인소.다인소분석현시혈청AFP>1000 ng/ml、간정맥침범、주위장기침범시간외복발적독립위험인소.결론 HCC근치성절제술후간외복발여술전혈청AFP>1000 ng/ml、간정맥침범、주위장기침범유관.대구유저사위험인소적환자술후응가강수방.
Objective To investigate the risk factors of extrahepatie recurrences after curative resection of primary hepatocellular carcinoma (HCC). Methods Clinicopathologic data of 238 curative resected cases of primary HCC were retrospectively reviewed for parameters affecting postoperative extrahepatic recurrences. Results During a median follow-up of 34 months (7 - 78 months), extrahepatic recurrences were observed in 32 out of 238 patients (13.4%). According to univariate analysis, the risk factors for extrahepatic recurrences were preoperative serum a-fetoprotein (AFP) level of > 1000 ng/ml,aspartate aminotransferase level of > 50 IU/L, presence of hepatic vein invasion, neighboring organ invasion, tumor satellites, and lack of tumor capsule formation. Preoperative serum AFP levels of > 1000 ng/ml, hepatic vein invasion, neighboring organ invasion proved to be independent risk factors by multivariate analysis. Conclusions Extrahepatic recurrences after curative resection of HCC was found to be related to preoperative serum AFP level of > 1000 ng/ml, hepatic vein invasion, and neighboring organ invasion.