糖脂联合毒性导致胰岛β细胞功能障碍
당지연합독성도치이도β세포공능장애
Combination of glucotoxicity and lipitoxicity impairs pancreatic β-cell function
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2009年 1期 28-29 ,共2页

    赵乃倩%余叶蓉%谭惠文%张祥迅

    조내천%여협용%담혜문%장상신

    糖毒性%脂毒性%胰岛β细胞功能%酮体生成 糖毒性%脂毒性%胰島β細胞功能%酮體生成
    당독성%지독성%이도β세포공능%동체생성
    Glucotoxicity%Lipitoxicity%Islet β-cell function%Ketone production
    采用静脉葡萄糖耐量试验及体外胰腺整体灌注的方法研究糖脂联合毒性对胰岛β细胞功能的影响.结果 发现,高血糖与高游离脂肪酸血症协同作用可严重损害肥胖大鼠胰岛β细胞的胰岛素分泌功能,导致酮体生成显著增加.
    채용정맥포도당내량시험급체외이선정체관주적방법연구당지연합독성대이도β세포공능적영향.결과 발현,고혈당여고유리지방산혈증협동작용가엄중손해비반대서이도β세포적이도소분비공능,도치동체생성현저증가.
    The effects of elevated levels of glucose and (or) free fatty acids on insulin secretion were studied in obese rats by intravenous glucose tolerance test and isolated pancreas perfusinn. The results showed that both glucose- and arginine-stimulated insulin secretions were severely impaired by glucolipotoxicity and the production of ketone was increased dramatically.
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