CAJ | 학술논문

目的探讨芳香化酶P450 mRNA在青春期乳房肥大症乳腺组织中的表达及意义.方法应用RT-PCR的方法测定15例青春期乳房肥大症乳腺组织中芳香化酶P450 mRNA的表达情况,并与15例正常乳腺组织中的芳香化酶P450 mRNA进行对比.结果芳香化酶P450 mRNA的阳性表达率在乳房肥大组与正常乳腺组间差异无统计学意义(P>0.05).芳香化酶P450 mRNA阳性表达的病例中,青春期乳房肥大症乳腺组织中的平均测定值为0.202±0.048,正常乳腺组织为0.159±0.068,两者比较差异有统计学意义(P<0.05).结论青春期乳房肥大症的发生、发展与乳腺组织中芳香化酶P450 mRNA的表达情况有关.
목적 탐토방향화매P450 mRNA재청춘기유방비대증유선조직중적표체급의의.방법 응용RT-PCR적방법측정15례청춘기유방비대증유선조직중방향화매P450 mRNA적표체정황,병여15례정상유선조직중적방향화매P450 mRNA진행대비.결과 방향화매P450 mRNA적양성표체솔재유방비대조여정상유선조간차이무통계학의의(P>0.05).방향화매P450 mRNA양성표체적병례중,청춘기유방비대증유선조직중적평균측정치위0.202±0.048,정상유선조직위0.159±0.068,량자비교차이유통계학의의(P<0.05).결론 청춘기유방비대증적발생、발전여유선조직중방향화매P450 mRNA적표체정황유관.
Objective To investigate the expression status of the P450arom mRNA in breast tissue of pubertal mammary hypertrophy and then explore the possible etiology of pubertal mammary hypertrophy. Methods 15 patients were selected for pubertal mammary hypertrophy group. Breast hypertrophy tissue specimens were collected from the gland excised during reduction mammaplasty. 15 patients with pathologically simple fibroadenoma were used as another control group. Patient approval of participation in this study was obtained preoperatively. The expression of P450arom mRNA was detected by RT-PCR in all the cases above. Results There was no significant difference between the pubertal mammary hypertrophy groups and normal groups on the expression rates of P450arom mRNA. But among the positive cases, the expression of P450arom mRNA within breast tissue were 0.202±0.048 in pubertal mammary hypertrophy group; and 0.159±0.068 in normal group. There was significant difference between the pubertal mammary hypertrophy and normal groups (P < 0.05). Conclusion The expression of P450arom mBNA in pubertal mammary hypertrophy are significantly higher than in normal mammary glandular tissue. The pubertal mammary hypertrophy may be related to the expression status of P450arom mRNA within breast tissue.