CAJ | 학술논문

目的:探讨针刺治疗偏头痛对降钙素基因相关肽(calatonin gene-ralatedpeptide,CGRP)、P物质、内皮素、神经肽Y、心钠素、神经降压肽(neurotensin,NT)的影响.方法:将40只SD大鼠数字表法随机分为正常对照组、模型对照组、针刺对照组和针刺治疗组.按各组方案造模,或针刺治疗后,采用放射免疫法测定颈静脉血浆中多种神经肽的含量.结果:模型对照组CGRP(319.64±53.12)ng/L;P物质(126.76±39.29)ng/L;心钠素(366.11±83.12)ng/L;内皮素(785.00±186.64)ng/L;神经肽Y(4 567.06±1 041.86)ng/L均较正常对照组(152.87±31.82),(57.43+21.03),(278.31±58.76),(516.88±126.89),(3 232.75±424.87)ng/L有明显升高(t=2.283～2.791,P＜0.05或0.01),而模型对照组NT(56.64±21.21)ng/L较正常对照组(113.12±35.92)ng/L明显降低(t=2.842,P＜0.01);针刺治疗组CGRP(148.54±19.18)ng/L;P物质(60.76±22.31)ng/L;心钠素(287.63±68.64)ng/L;内皮素(524.38±122.55)ng/L;神经肽Y(3 324.56±576.77)ng/L均明显下降(t=2.833～2.481,P＜0.05或P＜0.01),NT(101.13±27.69)ng/L较模型对照组明显升高(t=2.669,P＜0.05).结论:针刺调节脑神经肽的合成与释放,是其治疗偏头痛的主要因素之一.
목적:탐토침자치료편두통대강개소기인상관태(calatonin gene-ralatedpeptide,CGRP)、P물질、내피소、신경태Y、심납소、신경강압태(neurotensin,NT)적영향.방법:장40지SD대서수자표법수궤분위정상대조조、모형대조조、침자대조조화침자치료조.안각조방안조모,혹침자치료후,채용방사면역법측정경정맥혈장중다충신경태적함량.결과:모형대조조CGRP(319.64±53.12)ng/L;P물질(126.76±39.29)ng/L;심납소(366.11±83.12)ng/L;내피소(785.00±186.64)ng/L;신경태Y(4 567.06±1 041.86)ng/L균교정상대조조(152.87±31.82),(57.43+21.03),(278.31±58.76),(516.88±126.89),(3 232.75±424.87)ng/L유명현승고(t=2.283～2.791,P＜0.05혹0.01),이모형대조조NT(56.64±21.21)ng/L교정상대조조(113.12±35.92)ng/L명현강저(t=2.842,P＜0.01);침자치료조CGRP(148.54±19.18)ng/L;P물질(60.76±22.31)ng/L;심납소(287.63±68.64)ng/L;내피소(524.38±122.55)ng/L;신경태Y(3 324.56±576.77)ng/L균명현하강(t=2.833～2.481,P＜0.05혹P＜0.01),NT(101.13±27.69)ng/L교모형대조조명현승고(t=2.669,P＜0.05).결론:침자조절뇌신경태적합성여석방,시기치료편두통적주요인소지일.