中国中西医结合杂志
中國中西醫結閤雜誌
중국중서의결합잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2009年
10期
925-928
,共4页
史立宏%房春燕%李晓民%李金勇%牟华光
史立宏%房春燕%李曉民%李金勇%牟華光
사립굉%방춘연%리효민%리금용%모화광
抗过敏冲剂%慢性荨麻疹%调节激活正常T细胞表达和分泌的细胞因子%嗜酸粒细胞趋化因子%肿瘤坏死因子-α
抗過敏遲劑%慢性蕁痳疹%調節激活正常T細胞錶達和分泌的細胞因子%嗜痠粒細胞趨化因子%腫瘤壞死因子-α
항과민충제%만성담마진%조절격활정상T세포표체화분비적세포인자%기산립세포추화인자%종류배사인자-α
Anti-anaphylaxis Granules%chronic urticaria%regulated upon activation normal T cell expressed and secreted%eosinophil chemotactic factor%tumor necrosis factor-α
目的 观察抗过敏冲剂对慢性荨麻疹患者的疗效及其对血清调节激活正常T细胞表达和分泌的细胞因子(regulated upon activation normal T cell expressed and secreted,RANTES)、嗜酸粒细胞趋化因子(Eotaxin)、肿瘤坏死因子-α(TNF-α)水平的影响.方法 将51例慢性荨麻疹患者随机分为抗过敏冲剂组与西替利嗪组,采用ELISA法检测两组治疗前后血清RANTES、Eotaxin及TNF-α水平,并观察疗效.结果 抗过敏冲剂组有效率88.5%,西替利嗪组有效率64.0%,两组比较差异有统计学意义(P<0.05);且抗过敏冲剂组复发率[5.6%(1/18)]低于西替利嗪组[41.7%(5/12)],两组比较差异有统计学意义(P<0.05).慢性荨麻疹患者血清RANTES、Eotaxin及TNF-α水平较健康组明显升高(P<0.01),抗过敏冲剂能显著降低患者血清中过高的RANTES、Eotaxin与TNF-α水平(P<0.01).结论 抗过敏冲剂对慢性荨麻疹具有良好的疗效,调节RANTES、Eotaxin与TNF-α的血清水平可能是其作用机制.
目的 觀察抗過敏遲劑對慢性蕁痳疹患者的療效及其對血清調節激活正常T細胞錶達和分泌的細胞因子(regulated upon activation normal T cell expressed and secreted,RANTES)、嗜痠粒細胞趨化因子(Eotaxin)、腫瘤壞死因子-α(TNF-α)水平的影響.方法 將51例慢性蕁痳疹患者隨機分為抗過敏遲劑組與西替利嗪組,採用ELISA法檢測兩組治療前後血清RANTES、Eotaxin及TNF-α水平,併觀察療效.結果 抗過敏遲劑組有效率88.5%,西替利嗪組有效率64.0%,兩組比較差異有統計學意義(P<0.05);且抗過敏遲劑組複髮率[5.6%(1/18)]低于西替利嗪組[41.7%(5/12)],兩組比較差異有統計學意義(P<0.05).慢性蕁痳疹患者血清RANTES、Eotaxin及TNF-α水平較健康組明顯升高(P<0.01),抗過敏遲劑能顯著降低患者血清中過高的RANTES、Eotaxin與TNF-α水平(P<0.01).結論 抗過敏遲劑對慢性蕁痳疹具有良好的療效,調節RANTES、Eotaxin與TNF-α的血清水平可能是其作用機製.
목적 관찰항과민충제대만성담마진환자적료효급기대혈청조절격활정상T세포표체화분비적세포인자(regulated upon activation normal T cell expressed and secreted,RANTES)、기산립세포추화인자(Eotaxin)、종류배사인자-α(TNF-α)수평적영향.방법 장51례만성담마진환자수궤분위항과민충제조여서체리진조,채용ELISA법검측량조치료전후혈청RANTES、Eotaxin급TNF-α수평,병관찰료효.결과 항과민충제조유효솔88.5%,서체리진조유효솔64.0%,량조비교차이유통계학의의(P<0.05);차항과민충제조복발솔[5.6%(1/18)]저우서체리진조[41.7%(5/12)],량조비교차이유통계학의의(P<0.05).만성담마진환자혈청RANTES、Eotaxin급TNF-α수평교건강조명현승고(P<0.01),항과민충제능현저강저환자혈청중과고적RANTES、Eotaxin여TNF-α수평(P<0.01).결론 항과민충제대만성담마진구유량호적료효,조절RANTES、Eotaxin여TNF-α적혈청수평가능시기작용궤제.
Objective To investigate the therapeutic effect of Anti-anaphylaxis Granule(AAG)on chronic urticaria and its impact on cytokine of regulated upon activation of normal T cells expressed and secreted(RANTES),eosinophil chemotactic factor(Eotaxin)and tumor necrosis factor-α(TNF-α).Methods The therapeutic effects of AAG and cetirizine on chronic urticaria patients allocated in two groups were observed respectively,and the serum levels of RANTES,Eotaxin and TNF-α in patients were measured by ELISA before and after treatment,and were compared with those in normal subjects.Results The therapeutic effects of AAG group were better in effective rate(88.5% vs 64.0%)and lower in the recurrent rate(5.6% vs 41.9%)than those of cetirizine(all P<0.05).Serum levels of RANTES,Eotaxin and TNF-α in patients were higher than those in normal subjects(P<0.01),and they could be significantly reduced after AAG treatment(P<0.01).Conclusion AAG has favorite effect for treatment of chronic urticaria,its regulation on serum levels of RANTES,Eotaxin and TNF-α may be the mechanism of action.
