CAJ | 학술논문

背景:研究表明,脑黑质结构的病变是导致帕金森病的主要原因.从影像学角度来看,结构微小的黑质空间位置信息、体积以及3D结构形态的分析为帕金森病的临床诊断和治疗效果评价提供了十分有力的工具,因此其三维形态的研究工作尤为重要.由于恒河猴与人类的生理十分相似,这使它成为许多科学研究中比较理想的实验对象.目的:对传统的形状插值方法进行改进,并运用于恒河猴脑黑质断层图像.方法:较常用的形状插值方法是对变换后的相邻两层距离图像进行线性加权平均,从而获取中间层.试验中考虑多层相邻图像空间位置对插值图像的影响,然后进行非线性加权获取中间层.结果与结论:对插值的方法进行评估,评估结果比较令人满意,并运用于恒河猴脑黑质的三维重建中.该形状插值改进方法可以较好地运用于层片稀疏且结构细微的核团插值工作中,从而为与细微结构相关的疾病研究提供一定的参考价值.
배경:연구표명,뇌흑질결구적병변시도치파금삼병적주요원인.종영상학각도래간,결구미소적흑질공간위치신식、체적이급3D결구형태적분석위파금삼병적림상진단화치료효과평개제공료십분유력적공구,인차기삼유형태적연구공작우위중요.유우항하후여인류적생리십분상사,저사타성위허다과학연구중비교이상적실험대상.목적:대전통적형상삽치방법진행개진,병운용우항하후뇌흑질단층도상.방법:교상용적형상삽치방법시대변환후적상린량층거리도상진행선성가권평균,종이획취중간층.시험중고필다층상린도상공간위치대삽치도상적영향,연후진행비선성가권획취중간층.결과여결론:대삽치적방법진행평고,평고결과비교령인만의,병운용우항하후뇌흑질적삼유중건중.해형상삽치개진방법가이교호지운용우층편희소차결구세미적핵단삽치공작중,종이위여세미결구상관적질병연구제공일정적삼고개치.
BACKGROUND:Studies have shown that pathological change of substantia nigra (SN) is the main reason for Parkinson's disease (PD).From the medical imaging,spatial location,size and 3D morphology analysis of the tiny SN structure are very important to PD's diagnosis and treatment evaluation.As the physiology of rhesus monkey is much similar to human's,it has been used as an ideal experiment subject in many scientific researches.OBJECTIVE:To modify traditional shape-based interpolation method for SN structure of the rhesus monkey brain slices.METHODS:To gain the middle layers between two slices,traditional shape-based interpolation used linear weighted mean algorithm.However,considering the impact of adjacent multi-layer to the image,the middle layers were obtained by non-linear weight.RESULTS AND CONCLUSION:The new interpolation algorithm was assessed with a favorable results.Also,this method was applied to the 3D reconstruction of SN structure.The results show that the new interpolation method can be used in nucleus group interpolation with sparse slices and tiny structures,and offer reference to the related disease research.