CAJ | 학술논문

运用油包水微乳液方法制备了二吡啶甲基胺(dpa)及其锰(Ⅱ)和铁(Ⅲ)配合物修饰的Gd-DTPA配合物硅核壳纳米球,其中二吡啶甲基胺锰(Ⅱ)和铁(Ⅲ)配合物修饰的纳米球粒径分别为60和5 nm.体外MRI成像研究表明3种纳米球能显著提高肿瘤细胞的磁共振成像效果,具备良好的肿瘤靶向性.生物活性数据显示三价铁配合物修饰的纳米球具备成像和抑制细胞生长的双重功能,而锰配合物修饰的纳米球不能抑制肿瘤细胞的生长,可作为低毒性的肿瘤成像剂.实验结果显示肿瘤靶向性配合物修饰的纳米球可发展成为新型多功能肿瘤靶向性纳米药物.
운용유포수미유액방법제비료이필정갑기알(dpa)급기맹(Ⅱ)화철(Ⅲ)배합물수식적Gd-DTPA배합물규핵각납미구,기중이필정갑기알맹(Ⅱ)화철(Ⅲ)배합물수식적납미구립경분별위60화5 nm.체외MRI성상연구표명3충납미구능현저제고종류세포적자공진성상효과,구비량호적종류파향성.생물활성수거현시삼개철배합물수식적납미구구비성상화억제세포생장적쌍중공능,이맹배합물수식적납미구불능억제종류세포적생장,가작위저독성적종류성상제.실험결과현시종류파향성배합물수식적납미구가발전성위신형다공능종류파향성납미약물.
Di(picolyl)amine modified silica nanoparticles were prepared by W/O microemulsion method.The coordination of metal ions(Mn(Ⅱ)and Fe(Ⅲ))with di(pycolyl)amine modified nanoparticles produced two different size of nanospheres with the hydrodynamic diameter of approximately 60 nm and 5 nm,respectively.Three grafted silica nanospheres all display a great contrast enhancement in vitro indicating that they could accumulate in cancer cell,selectively.The Fe(Ⅲ)-di(picolyl)amine complex modified nanosphere was a multifunctional nanoparticle to image and inhibit the proliferation of cancer cells,and (Mn(Ⅱ)-di(picolyl)amine codex modified nanosphere could only be used as a low toxic MRI agents.So antitumor complexes modified nanospheres would be new kinds of multifunctional nanoparticles to target the cancer cells actively through complex induced active intracellular accumulating.