国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2008年
4期
224-226
,共3页
内分泌眼病%白细胞介素1β%碘放射性同位素%放射免疫测定
內分泌眼病%白細胞介素1β%碘放射性同位素%放射免疫測定
내분비안병%백세포개소1β%전방사성동위소%방사면역측정
Thyriod eye disease%Interleukin-1β%Iodine radioisotopes%Radioimmunoassay
目的 获得内分泌性眼病的自身免疫病理变化过程中机体的相关细胞因子白细胞介素113(IL-1β)表达痕迹的数据,探讨131I治疗甲亢后对合并内分泌性眼病患者外周血中IL-1β水平的影响.方法 采用前瞻性调查方法,选取内分泌性眼病患者31例,均有眼部症状和体征,血清甲状腺激素水平高于正常范围,并经眼眶CT检查排除其他疾病所导致的突眼,131I治疗剂量按照公式计算IL-1β的检测采用放射免疫分析法.结果 内分泌性眼病组较正常对照组血清IL-1β水平有不同程度升高:治疗前[(0.15±0.07)ng/ml]治疗后[(0.11±0.05)ng/ml]正常对照组[(0.10±0.03)ng/ml],H=68.088,P<0.001;131I治疗后较治疗前内分泌性眼病患者血清IL-1β水平亦有所下降(H=88.56,P<0.001);治疗后内分泌性眼病患者突眼度亦得到改善外周血中IL-1β水平与内分泌性眼病发病密切相关,并且内分泌性眼病患者经131I治疗后血清IL-1β水平较治疗前有所下降,突眼症状也明显改善.
目的 穫得內分泌性眼病的自身免疫病理變化過程中機體的相關細胞因子白細胞介素113(IL-1β)錶達痕跡的數據,探討131I治療甲亢後對閤併內分泌性眼病患者外週血中IL-1β水平的影響.方法 採用前瞻性調查方法,選取內分泌性眼病患者31例,均有眼部癥狀和體徵,血清甲狀腺激素水平高于正常範圍,併經眼眶CT檢查排除其他疾病所導緻的突眼,131I治療劑量按照公式計算IL-1β的檢測採用放射免疫分析法.結果 內分泌性眼病組較正常對照組血清IL-1β水平有不同程度升高:治療前[(0.15±0.07)ng/ml]治療後[(0.11±0.05)ng/ml]正常對照組[(0.10±0.03)ng/ml],H=68.088,P<0.001;131I治療後較治療前內分泌性眼病患者血清IL-1β水平亦有所下降(H=88.56,P<0.001);治療後內分泌性眼病患者突眼度亦得到改善外週血中IL-1β水平與內分泌性眼病髮病密切相關,併且內分泌性眼病患者經131I治療後血清IL-1β水平較治療前有所下降,突眼癥狀也明顯改善.
목적 획득내분비성안병적자신면역병리변화과정중궤체적상관세포인자백세포개소113(IL-1β)표체흔적적수거,탐토131I치료갑항후대합병내분비성안병환자외주혈중IL-1β수평적영향.방법 채용전첨성조사방법,선취내분비성안병환자31례,균유안부증상화체정,혈청갑상선격소수평고우정상범위,병경안광CT검사배제기타질병소도치적돌안,131I치료제량안조공식계산IL-1β적검측채용방사면역분석법.결과 내분비성안병조교정상대조조혈청IL-1β수평유불동정도승고:치료전[(0.15±0.07)ng/ml]치료후[(0.11±0.05)ng/ml]정상대조조[(0.10±0.03)ng/ml],H=68.088,P<0.001;131I치료후교치료전내분비성안병환자혈청IL-1β수평역유소하강(H=88.56,P<0.001);치료후내분비성안병환자돌안도역득도개선외주혈중IL-1β수평여내분비성안병발병밀절상관,병차내분비성안병환자경131I치료후혈청IL-1β수평교치료전유소하강,돌안증상야명현개선.
Objective To obtain the level of IL-1β in auto-immue pathological processes of thyroid eye disease patients treated with 131I.Methods By the prepositive dig,nose,a total of 31 patients of thyroid eye disease was investigated.They all had opthalmic symptoms,their thyroid hormones were higher than that of normal persons.These patients were foreclosed the ophthalmology caused by other diseases making use of the orbit CT.The degree of binocular exopthalmos was measured by a specialist.The dosage of 131I treatment according to formula calculation.To detect the serum level of IL-1β by radioimmunoassay.Results The serum level of IL-1β in thyroid eye disease group is higher than that of control group in some degree (pretherapeutic level of IL-1β is (0.15±0.07) ng/ml,therapeutic level of IL-1β is (0.11±0.05) ng/ml,normal control is (0.10±0.03)ng/ml,H=68.088,P<0.001.After 131I treatment,serum level of IL-1β were dropped in thyroid eye disease patients(H=88.56,P<0.001),and the degree of ophthalmic symptom was also mended.Conclusion The level of IL-1β in peripheral blood of thyroid eye disease patients is closely associated with morbility,and there is a reduction of IL-1β level in the serum of thyroid eye disease patient after <131I treatment compared with that before treatment,also there is a significant improvement after treatment.
