国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
11期
998-1000
,共3页
孟宏%时宇静%郝晋东%刘冷
孟宏%時宇靜%郝晉東%劉冷
맹굉%시우정%학진동%류랭
湿热证%大鼠模型%针刺研究
濕熱證%大鼠模型%針刺研究
습열증%대서모형%침자연구
Damp-heat syndrome%Rat model%Experimental research
目的 观察针刺阴陵泉、内庭对湿热证大鼠模型的影响.方法 采用高脂饮食、湿热环境、大肠杆菌感染联用方法制作大鼠湿热证模型.造模后给予针刺治疗10 d.结果 造模大鼠症状和体征都有变化,符合湿热证的特点;且高、中、低切变率下的全血黏度[(2.95±0.18)、(3.31±0.20)、(9.52±0.53)]mPa?s,血清及皮肤组织中SOD和MDA表达均有异常[(4.21±0.3)、(8.51±0.42)]mPa?s,[(1.35±0.16)、(1.26±0.20)]mPa?s.针刺组对高、中、低切变率下的全血黏度[(2.70±0.15)、(2.98±0.27)、(8.93±0.80)]mPa?s,血清及皮肤组织中SOD和MDA表达量均有明显改善[(4.52±0.26)、(7.00±0.62)]mPa?s,[(1.49±0.12)、(1.05±0.24)]mPa?s.结论 针刺阴陵泉穴和内庭穴可改善湿热证大鼠模型的血液高黏状态,提高机体清除过氧化物能力.
目的 觀察針刺陰陵泉、內庭對濕熱證大鼠模型的影響.方法 採用高脂飲食、濕熱環境、大腸桿菌感染聯用方法製作大鼠濕熱證模型.造模後給予針刺治療10 d.結果 造模大鼠癥狀和體徵都有變化,符閤濕熱證的特點;且高、中、低切變率下的全血黏度[(2.95±0.18)、(3.31±0.20)、(9.52±0.53)]mPa?s,血清及皮膚組織中SOD和MDA錶達均有異常[(4.21±0.3)、(8.51±0.42)]mPa?s,[(1.35±0.16)、(1.26±0.20)]mPa?s.針刺組對高、中、低切變率下的全血黏度[(2.70±0.15)、(2.98±0.27)、(8.93±0.80)]mPa?s,血清及皮膚組織中SOD和MDA錶達量均有明顯改善[(4.52±0.26)、(7.00±0.62)]mPa?s,[(1.49±0.12)、(1.05±0.24)]mPa?s.結論 針刺陰陵泉穴和內庭穴可改善濕熱證大鼠模型的血液高黏狀態,提高機體清除過氧化物能力.
목적 관찰침자음릉천、내정대습열증대서모형적영향.방법 채용고지음식、습열배경、대장간균감염련용방법제작대서습열증모형.조모후급여침자치료10 d.결과 조모대서증상화체정도유변화,부합습열증적특점;차고、중、저절변솔하적전혈점도[(2.95±0.18)、(3.31±0.20)、(9.52±0.53)]mPa?s,혈청급피부조직중SOD화MDA표체균유이상[(4.21±0.3)、(8.51±0.42)]mPa?s,[(1.35±0.16)、(1.26±0.20)]mPa?s.침자조대고、중、저절변솔하적전혈점도[(2.70±0.15)、(2.98±0.27)、(8.93±0.80)]mPa?s,혈청급피부조직중SOD화MDA표체량균유명현개선[(4.52±0.26)、(7.00±0.62)]mPa?s,[(1.49±0.12)、(1.05±0.24)]mPa?s.결론 침자음릉천혈화내정혈가개선습열증대서모형적혈액고점상태,제고궤체청제과양화물능력.
Objective To observe the effect of acupuncture on rat model with damp-heat syndrome.Methods The combined use of high fat diet,damp-heat environment and infection of bacillus coli was adopted to establish rat models with damp-heat syndrome.A 10-day acupuncture treatment was given to the models.Results Changes can be found in both symptoms and signs of the model rat,which were held to meet the features of damp-heat syndrome.Moreover,abnormity can be found in the expression of the whole blood viscosity [(2.95 ±0.18)、(3.31±0.20)、(9.52±0.53)]mPa ? s,the expression of SOD and MDA of the blood serum and the skin [(4.21 ± 0.3)、(8.51 ± 0.42)]mPa ? s and [( 1.35 ± 0.16)、(1.26 ± 0.20)]mPa ? s.under high,medium and low shear rate.And improvements can be found in the expression of the whole blood viscosity [(2.70± 0.15)、(2.98 ±0.27)、(8.93 ± 0.80)]mPa ? s,the expression of SOD and MDA of the blood serum and the skin [(4.52 ± 0.26)、(7.00 - 0.62)]mPa ? s,[( 1.49 ± 0.12)、( 1.05 ± 0.24)]mPa ? s under high,medium and low shear rate.Conclusion Acupuncture at Yinlingquan (SP9) and Neiting (ST44) can improve the high blood viscosity situation of rat model with damp-heat syndrome,and enhance the ability of the body to eliminate hyperoxide as well.
