CAJ | 학술논문

慢性淋巴细胞白血病(CLL)细胞既是肿瘤细胞又是免疫细胞,这种病态细胞免疫功能紊乱,可诱发各种自身免疫疾病,且以血液系统自身免疫疾病为主,表现为红细胞、血小板或白细胞的减少.其发病机制尚不清楚,临床上容易误诊、漏诊.总体上的治疗策略与治疗原发性自身免疫疾病类似,主要问题是如何在治疗自身免疫疾病的同时也兼顾到CLL.
만성림파세포백혈병(CLL)세포기시종류세포우시면역세포,저충병태세포면역공능문란,가유발각충자신면역질병,차이혈액계통자신면역질병위주,표현위홍세포、혈소판혹백세포적감소.기발병궤제상불청초,림상상용역오진、루진.총체상적치료책략여치료원발성자신면역질병유사,주요문제시여하재치료자신면역질병적동시야겸고도CLL.
The chronic lymphocytic leukemia cells are not only tumor cells, but also immune cells. Dysfunction of these tumor cells can induce many kinds of autoimmune diseases, which mainly are hematological complications. The clinical manifestations involve decreased amount of erythrocytes, platelets, or leukocytes. The pathogenesis of such complications is not very clear. Misdiagnoses and missed diagnoses often occur. Generally, the treatment protocols are similar to those of primary autoimmune diseases. The main concerns are how to give considerations to both chronic lymphocytic leukemia and autoimmune diseases simultaneously.