中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
8期
31-33
,共3页
乳腺肿瘤%免疫组织化学%乳腺癌易感基因1
乳腺腫瘤%免疫組織化學%乳腺癌易感基因1
유선종류%면역조직화학%유선암역감기인1
Breast neoplasms%Immunohistochemistry%Breast cancer susceptibility gene 1
目的 研究乳腺癌易感基因1(BRCA1)在散发性乳腺癌中的表达与各病理学指标之间的相关性.方法 应用SABC免疫组化染色法对30例乳腺纤维腺瘤和42例乳腺癌患者的病变组织中BRCA1的表达进行检测,并与腋窝淋巴结转移、肿瘤大小、组织学类型和组织学分级进行相关分析.结果 BRCA1在乳腺纤维腺瘤中的阳性表达率为85.7%(36/42),在乳腺癌中的阳性表达率为52.4%(22/42),乳腺癌中腋窝有淋巴结转移的BRCA1阳性表达率明显低于无淋巴结转移的BRCA1阳性表达率(P<0.05),BRCA1在乳腺癌中的阳性表达率随着组织学分级的升高有逐渐下降趋势,其中Ⅰ级和Ⅲ级、Ⅱ级和Ⅲ级比较差异有统计学意义(P<0.05),Ⅰ级与Ⅱ级比较差异无统计学意义(P>0.05),BRCA1的表达与肿瘤的组织学类型、肿块大小无关(P值均>0.05).结论 BRCA1在乳腺癌的发生、发展过程中有重要的作用,它有可能成为临床对乳腺癌治疗和判断预后的一个生物学指标.
目的 研究乳腺癌易感基因1(BRCA1)在散髮性乳腺癌中的錶達與各病理學指標之間的相關性.方法 應用SABC免疫組化染色法對30例乳腺纖維腺瘤和42例乳腺癌患者的病變組織中BRCA1的錶達進行檢測,併與腋窩淋巴結轉移、腫瘤大小、組織學類型和組織學分級進行相關分析.結果 BRCA1在乳腺纖維腺瘤中的暘性錶達率為85.7%(36/42),在乳腺癌中的暘性錶達率為52.4%(22/42),乳腺癌中腋窩有淋巴結轉移的BRCA1暘性錶達率明顯低于無淋巴結轉移的BRCA1暘性錶達率(P<0.05),BRCA1在乳腺癌中的暘性錶達率隨著組織學分級的升高有逐漸下降趨勢,其中Ⅰ級和Ⅲ級、Ⅱ級和Ⅲ級比較差異有統計學意義(P<0.05),Ⅰ級與Ⅱ級比較差異無統計學意義(P>0.05),BRCA1的錶達與腫瘤的組織學類型、腫塊大小無關(P值均>0.05).結論 BRCA1在乳腺癌的髮生、髮展過程中有重要的作用,它有可能成為臨床對乳腺癌治療和判斷預後的一箇生物學指標.
목적 연구유선암역감기인1(BRCA1)재산발성유선암중적표체여각병이학지표지간적상관성.방법 응용SABC면역조화염색법대30례유선섬유선류화42례유선암환자적병변조직중BRCA1적표체진행검측,병여액와림파결전이、종류대소、조직학류형화조직학분급진행상관분석.결과 BRCA1재유선섬유선류중적양성표체솔위85.7%(36/42),재유선암중적양성표체솔위52.4%(22/42),유선암중액와유림파결전이적BRCA1양성표체솔명현저우무림파결전이적BRCA1양성표체솔(P<0.05),BRCA1재유선암중적양성표체솔수착조직학분급적승고유축점하강추세,기중Ⅰ급화Ⅲ급、Ⅱ급화Ⅲ급비교차이유통계학의의(P<0.05),Ⅰ급여Ⅱ급비교차이무통계학의의(P>0.05),BRCA1적표체여종류적조직학류형、종괴대소무관(P치균>0.05).결론 BRCA1재유선암적발생、발전과정중유중요적작용,타유가능성위림상대유선암치료화판단예후적일개생물학지표.
Objective To study the relationship between the expression of breast cancer susceptibility gene (BRCA)1 and the pathological parameters in sporadic breast cancer. Method Immunohistochemistry was used to detect the expression of BRCA1 in 42 cases of breast cancer tissues and 30 cases of breast fibroadenoma tissues and analyzed the correlation of the results with other parameters which included tumor size,tumor type,histological grade and axillary lymph nodes metastases. Results The positive expression rate of BRCA1 was 52.4% (22/42) in breast cancer patients and 85.7% (36/42) in breast fibroadenoma patients. The lower positive expression rate of BRCA1 was found in axillary lymph nodes metastases (P < 0.05). The positive expression rate in stage Ⅲ of breast cancer was lower than that in stage Ⅰ (P < 0.05 ) and was also lower than that in stage Ⅱ (P < 0.05 ), but there was no significant difference between stage Ⅰ and stage Ⅱ (P > 0.05). No significant correlation was observed among expression of BRCA1 and tumor size, tumor type (P > 0.05). Conclusions BRCA1 plays an important role in pathogenesis and development of breast cancer.BRCA1 maybe a adjuvant index for treating breast cancer and estimating prognosis.
