中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
4期
390-393
,共4页
甲状腺功能%冠状动脉粥样硬化性心脏病%冠状动脉痉挛
甲狀腺功能%冠狀動脈粥樣硬化性心髒病%冠狀動脈痙攣
갑상선공능%관상동맥죽양경화성심장병%관상동맥경련
Thyroid function%Coronary artery disease%Coronary artery spasm
目的 探讨甲状腺功能异常与冠状动脉粥样硬化性心脏病的关系.方法 选取北京协和医院2003年1月至2010年2月期间经冠状动脉造影证实有冠心病的2012例患者,通过甲状腺功能检查分为甲状腺功能正常组、甲状腺功能亢进组和甲状腺功能减退组,比较3组间危险因素和冠状动脉造影结果差异.结果 甲状腺功能亢进患者高血压、高血脂、糖尿病的患病率低于甲状腺功能正常及甲状腺功能减退患者(高血压:40%与69.4%与7 8.6%,x2=4.061,P=0.01;高血脂:20.0%与67.4%与85.7%,x2=12.331,P=0.002;糖尿病:20.0%与41.6%与35.7%,x2=2.114,P=0.347);冠脉造影证实甲状腺功能减退患者的冠心病发生率(71.0%)高于甲状腺功能亢进患者(55.2%),但差异无统计学意义(x2=1.804,P=0.179);2例甲状腺功能亢进患者出现冠状动脉痉挛并发生急性心肌梗死.结论 甲状腺功能减退相比甲状腺功能亢进增加冠心病发病率;甲状腺激素水平的升高可能增加了冠脉痉挛和急性心梗的发生概率,但药物治疗后预后良好.
目的 探討甲狀腺功能異常與冠狀動脈粥樣硬化性心髒病的關繫.方法 選取北京協和醫院2003年1月至2010年2月期間經冠狀動脈造影證實有冠心病的2012例患者,通過甲狀腺功能檢查分為甲狀腺功能正常組、甲狀腺功能亢進組和甲狀腺功能減退組,比較3組間危險因素和冠狀動脈造影結果差異.結果 甲狀腺功能亢進患者高血壓、高血脂、糖尿病的患病率低于甲狀腺功能正常及甲狀腺功能減退患者(高血壓:40%與69.4%與7 8.6%,x2=4.061,P=0.01;高血脂:20.0%與67.4%與85.7%,x2=12.331,P=0.002;糖尿病:20.0%與41.6%與35.7%,x2=2.114,P=0.347);冠脈造影證實甲狀腺功能減退患者的冠心病髮生率(71.0%)高于甲狀腺功能亢進患者(55.2%),但差異無統計學意義(x2=1.804,P=0.179);2例甲狀腺功能亢進患者齣現冠狀動脈痙攣併髮生急性心肌梗死.結論 甲狀腺功能減退相比甲狀腺功能亢進增加冠心病髮病率;甲狀腺激素水平的升高可能增加瞭冠脈痙攣和急性心梗的髮生概率,但藥物治療後預後良好.
목적 탐토갑상선공능이상여관상동맥죽양경화성심장병적관계.방법 선취북경협화의원2003년1월지2010년2월기간경관상동맥조영증실유관심병적2012례환자,통과갑상선공능검사분위갑상선공능정상조、갑상선공능항진조화갑상선공능감퇴조,비교3조간위험인소화관상동맥조영결과차이.결과 갑상선공능항진환자고혈압、고혈지、당뇨병적환병솔저우갑상선공능정상급갑상선공능감퇴환자(고혈압:40%여69.4%여7 8.6%,x2=4.061,P=0.01;고혈지:20.0%여67.4%여85.7%,x2=12.331,P=0.002;당뇨병:20.0%여41.6%여35.7%,x2=2.114,P=0.347);관맥조영증실갑상선공능감퇴환자적관심병발생솔(71.0%)고우갑상선공능항진환자(55.2%),단차이무통계학의의(x2=1.804,P=0.179);2례갑상선공능항진환자출현관상동맥경련병발생급성심기경사.결론 갑상선공능감퇴상비갑상선공능항진증가관심병발병솔;갑상선격소수평적승고가능증가료관맥경련화급성심경적발생개솔,단약물치료후예후량호.
Objective To study the relationship between the thyroid dysfunction and coronary artery disease (CAD). Methods Two thousands and twelve patients,diagnosed as CAD by coronary angiography from January 2003 to February 2010 in Peking Union Hospital,were enrolled into this study and divided into normal thyroid function, hyperthyroidism, and hypothyroidism groups. The thyroid function data and the coronary angiography findings were compared among three groups. Results The incidence rates of hypertension (40%vs. 69. 4% vs. 78.6%, x2 = 12. 331, P = 0. 01) and hyperlipemia(20. 0% vs. 67.4% vs. 85.7%, x2 =12. 331 ,P=0. 002) in hyperthyroidism patients were significantly lower than normal thyroid function patients and hypothyroidism patients, but no significant differences were found in the comparison of diabetes incidence rates among three groups (20. 0% vs. 41.6% vs. 35.7%, x2 = 2. 114,P =0. 347). According to the coronary angiography findings, we found that the incidence rate of CAD of hypothyroidism patients was higher than hyperthyroidism patients(71.0% vs. 55. 2%, x2. = 1. 804, P = 0. 179), but the difference didn' t reach statistically significant level. Two hyperthyroidism patients had coronary artery spasm and acute myocardial infarction. Conclusion Hypothyroidism had more promotion effect on coronary artery disease than hyperthyroidism,but higher serum thyroxin level increased the risk of coronary spasm and the probability of acute myocardial infarction,which could be well adjusted by medication treatment.
