CAJ | 학술논문

目的评价缬沙坦和阿托托他汀联合胺碘酮治疗阵发性心房颤动的临床疗效.方法 120例阵发性心房颤动患者完全随机分为治疗组(68例)和对照组(52例),全部患者经过口服或静脉注射胺碘酮或电复律恢复窦性心律后,对照组给予胺碘酮口服,第1周600 mg/d,第2周减至400 mg/d,第3周减至200mg/d,并以200 mg/d剂量用药至满1年.治疗组加用缬沙坦80 mg/d,阿托伐他汀钙胶囊10mg/晚.观察2组患者治疗第3、6、9、12个月的窦性心律维持率.结果治疗3个月,治疗组、对照组窦性心律维持率分别为91.2％ (62/68)、86.5％ (45/52),2组差异无统计学意义(P＞0.05)；治疗6、9和12个月,治疗组和对照组窭性心律维持率分别为86.8％( 59/68)、85.3％ (58/68)、82.4％(56/68)和71.2％( 37/52)、65.4％( 34/52)、59.6％(31/52),差异有统计学意义(P＜0.05).结论缬沙坦和阿托伐他汀联合胺碘酮治疗阵发性心房颤动疗效优于单用胺碘酮治疗.
목적 평개힐사탄화아탁탁타정연합알전동치료진발성심방전동적림상료효.방법 120례진발성심방전동환자완전수궤분위치료조(68례)화대조조(52례),전부환자경과구복혹정맥주사알전동혹전복률회복두성심률후,대조조급여알전동구복,제1주600 mg/d,제2주감지400 mg/d,제3주감지200mg/d,병이200 mg/d제량용약지만1년.치료조가용힐사탄80 mg/d,아탁벌타정개효낭10mg/만.관찰2조환자치료제3、6、9、12개월적두성심률유지솔.결과 치료3개월,치료조、대조조두성심률유지솔분별위91.2％ (62/68)、86.5％ (45/52),2조차이무통계학의의(P＞0.05)；치료6、9화12개월,치료조화대조조구성심률유지솔분별위86.8％( 59/68)、85.3％ (58/68)、82.4％(56/68)화71.2％( 37/52)、65.4％( 34/52)、59.6％(31/52),차이유통계학의의(P＜0.05).결론 힐사탄화아탁벌타정연합알전동치료진발성심방전동료효우우단용알전동치료.
Objective To evaluate the clinical effect of valsartan,atorvastatin combined with amiodarone on patients with paroxysmal atrial fibrillation to maintain sinus rhythm.Methods One hundred and twenty patients with paroxysmal atrial fibrillation were chosen and divided into treatment group (68 cases) and control group (52 cases).After all patients recovered sinus rhythm via taking amiodarone orally or intravenous injection or electrical conversion.The control group took 600 mg of amiodarone orally each day in the first week,400 mg per day in the second week,200 mg per day in the third week and maintained 200 mg per day afterwards.The treatment group used additional 80 mg of valsartan each day and 10 mg of atorvastatin calcium capsule every night.The maintenance ratio of sinus rhythm of the two groups of patients after three,six,nine and twdve months of treatment was observed.Results After three months of treatment,the maintenance ratio of sinus rhythm of treatment group and control group were 91.2％ (62/68) and 86.5％ (45/52) respectively.The difference between the two groups had no statistical significance(P ＞0.05).After six,nine and twelve months of treatment,the maintenance ratio (％) of sinus rhythm of treatment group/control group was 86.8％ (59/68),85.3％ (58/68),82.4％ (56/68) ; 71.2％ (37/52),65.4％ ( 34/52 ),59.6％ ( 31/52 ),respectively.The differences had statistical significance ( P ＜ 0.05).Conclusion The curative effect of valsartan,atorvastatin combined with amiodarone on the patients with paroxysmal atrial fibrillation to maintain sinus rhythm is better than that of the treatment with only amiodarone.