中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
9期
741-743
,共3页
薛海波%马蕾%王秀云%刘俊英%周荣佼%张立
薛海波%馬蕾%王秀雲%劉俊英%週榮佼%張立
설해파%마뢰%왕수운%류준영%주영교%장립
桥本甲状腺炎%巨噬细胞移动抑制因子%甲状腺%自身免疫
橋本甲狀腺炎%巨噬細胞移動抑製因子%甲狀腺%自身免疫
교본갑상선염%거서세포이동억제인자%갑상선%자신면역
Hashimoto's thyroiditis%Macrophage migration inhibitory factor%Thyriod gland%Autoimmunity
以实时定量PCR及ELISA法检测桥本甲状腺炎(HT)患者和健康对照者外周血单个核细胞(PBMC)中巨噬细胞移动抑制因子(MIF)mRNA表达及血清中MIF蛋白水平,结果显示HT患者PBMC(Z=-4.276,P<0.01)、血清中MIF(Z=-5.358,P<0.01)水平增高,与甲状腺特异性自身抗体及TSH水平正相关.
以實時定量PCR及ELISA法檢測橋本甲狀腺炎(HT)患者和健康對照者外週血單箇覈細胞(PBMC)中巨噬細胞移動抑製因子(MIF)mRNA錶達及血清中MIF蛋白水平,結果顯示HT患者PBMC(Z=-4.276,P<0.01)、血清中MIF(Z=-5.358,P<0.01)水平增高,與甲狀腺特異性自身抗體及TSH水平正相關.
이실시정량PCR급ELISA법검측교본갑상선염(HT)환자화건강대조자외주혈단개핵세포(PBMC)중거서세포이동억제인자(MIF)mRNA표체급혈청중MIF단백수평,결과현시HT환자PBMC(Z=-4.276,P<0.01)、혈청중MIF(Z=-5.358,P<0.01)수평증고,여갑상선특이성자신항체급TSH수평정상관.
The levels of macrophage migration inhibitory factor (MIF) in peripheral blood mononuclear cell (PBMC) and serum in patients with Hashimoto's thyroiditis (HT) were detected by real-time PCR and ELISA,respectively.The results revealed that the expression of MIF mRNA in PBMC ( Z =-4.276,P<0.01 ) and protein level in serum ( Z=-5.358,P<0.01 ) were increased in HT patients,and positively correlated with thyroid specific autoantibodies and TSH levels.