中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2008年
12期
1217-1219
,共3页
NAD(P)H氧化酶%基因多态性%短暂性脑缺血发作
NAD(P)H氧化酶%基因多態性%短暫性腦缺血髮作
NAD(P)H양화매%기인다태성%단잠성뇌결혈발작
NAD(P) H oxidase%Polymorphism%Transient ischemic attack
目的 探讨NAD(P)H氧化酶p22phox亚基C242T基因多态性与短暂性脑缺血发作(TIA)的相关性.方法 收集138例TIA患者及130例健康对照者,用聚合酶链反应(PCR)及限制性片段长度多态性分析(RFLP)的方法确定其基因型,比较其在不同人群中的分布特点.结果 TIA组和对照组的CT基因型频率分别为0.268和0.139.未发现有TT基因型.TLA组的CT基因型频率明显高于对照组.T等位基因频率亦高于对照组,差异均有统计学意义(P<0.05).结论 推测NAD(P)H氧化酶p22phox亚基C242T多念性为TIA的一个危险因素.
目的 探討NAD(P)H氧化酶p22phox亞基C242T基因多態性與短暫性腦缺血髮作(TIA)的相關性.方法 收集138例TIA患者及130例健康對照者,用聚閤酶鏈反應(PCR)及限製性片段長度多態性分析(RFLP)的方法確定其基因型,比較其在不同人群中的分佈特點.結果 TIA組和對照組的CT基因型頻率分彆為0.268和0.139.未髮現有TT基因型.TLA組的CT基因型頻率明顯高于對照組.T等位基因頻率亦高于對照組,差異均有統計學意義(P<0.05).結論 推測NAD(P)H氧化酶p22phox亞基C242T多唸性為TIA的一箇危險因素.
목적 탐토NAD(P)H양화매p22phox아기C242T기인다태성여단잠성뇌결혈발작(TIA)적상관성.방법 수집138례TIA환자급130례건강대조자,용취합매련반응(PCR)급한제성편단장도다태성분석(RFLP)적방법학정기기인형,비교기재불동인군중적분포특점.결과 TIA조화대조조적CT기인형빈솔분별위0.268화0.139.미발현유TT기인형.TLA조적CT기인형빈솔명현고우대조조.T등위기인빈솔역고우대조조,차이균유통계학의의(P<0.05).결론 추측NAD(P)H양화매p22phox아기C242T다념성위TIA적일개위험인소.
Objective To investigate the correlation between NAD (P)H oxidase p22phox C242T polymorphism and transient ischemic attack (TIA). Methods This study involved 138 Chinese patients with TIA and 130 control subjects, from whom genomic DNA was obtained to determine the p22phox C242T polymorphism using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results The CT genotype frequencies in the TIA group and control group were 0.268 and 0.139, respectively, and no TT genotype was found. The CT genotype and T allele frequency of the TIA group was significant higher than that of the control group (p<0.05). Conclusion The NAD(P)H oxidase p22phox C242T polymorphism may serve as a risk factor for TIA.
