国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2010年
3期
161-164
,共4页
钟兴祥%刘思平%郑吉祥%王菊新%张小文%范鸿登
鐘興祥%劉思平%鄭吉祥%王菊新%張小文%範鴻登
종흥상%류사평%정길상%왕국신%장소문%범홍등
前列腺肿瘤%前列腺增生%荧光免疫测定%前列腺特异抗原%诊断,鉴别
前列腺腫瘤%前列腺增生%熒光免疫測定%前列腺特異抗原%診斷,鑒彆
전렬선종류%전렬선증생%형광면역측정%전렬선특이항원%진단,감별
Prostatic neoplasms%Prostatic hyperplasia%Fluoroimmunoassay%Prostate-specific antigen%Diagnosis,differential
目的 探讨血清中游离前列腺特异性抗原(FPSA)/总前列腺特异性抗原(TPSA)值在鉴别诊断前列腺癌中的临床价值.方法 选取良性前列腺增生患者115例、前列腺癌患者58例、排除前列腺疾病的门诊健康体检者60例,采用时间分辨荧光免疫分析法测定血清TPSA、FPSA及FPSA/TPSA值,进行统计学分析.结果 TPSA为4.0～45.5 μg/L时,良性前列腺增生患者和前列腺癌患者交叉重叠,在此区域内,两组患者数差异无统计学意义(t=1.76,P＞0.05),而两组患者FPSA/TPSA值却有显著差异(t=2.74,P＜0.05),具有较大的鉴别诊断价值.以FPSA/TPSA值≤0.15作为鉴别诊断前列腺癌的参考值,既保持了较高的灵敏度(91.5%),又提高了特异度(78.6%)和准确率(79.8%),并在一定程度上提高了阳性预测值(82.5%)和阴性预测值(96.5%).结论 FPSA/TPSA值不但能够弥补单用TPSA的不足,提高前列腺癌的早期检出率,同时减少不必要的活检,值得进一步推广应用.
目的 探討血清中遊離前列腺特異性抗原(FPSA)/總前列腺特異性抗原(TPSA)值在鑒彆診斷前列腺癌中的臨床價值.方法 選取良性前列腺增生患者115例、前列腺癌患者58例、排除前列腺疾病的門診健康體檢者60例,採用時間分辨熒光免疫分析法測定血清TPSA、FPSA及FPSA/TPSA值,進行統計學分析.結果 TPSA為4.0～45.5 μg/L時,良性前列腺增生患者和前列腺癌患者交扠重疊,在此區域內,兩組患者數差異無統計學意義(t=1.76,P＞0.05),而兩組患者FPSA/TPSA值卻有顯著差異(t=2.74,P＜0.05),具有較大的鑒彆診斷價值.以FPSA/TPSA值≤0.15作為鑒彆診斷前列腺癌的參攷值,既保持瞭較高的靈敏度(91.5%),又提高瞭特異度(78.6%)和準確率(79.8%),併在一定程度上提高瞭暘性預測值(82.5%)和陰性預測值(96.5%).結論 FPSA/TPSA值不但能夠瀰補單用TPSA的不足,提高前列腺癌的早期檢齣率,同時減少不必要的活檢,值得進一步推廣應用.
목적 탐토혈청중유리전렬선특이성항원(FPSA)/총전렬선특이성항원(TPSA)치재감별진단전렬선암중적림상개치.방법 선취량성전렬선증생환자115례、전렬선암환자58례、배제전렬선질병적문진건강체검자60례,채용시간분변형광면역분석법측정혈청TPSA、FPSA급FPSA/TPSA치,진행통계학분석.결과 TPSA위4.0～45.5 μg/L시,량성전렬선증생환자화전렬선암환자교차중첩,재차구역내,량조환자수차이무통계학의의(t=1.76,P＞0.05),이량조환자FPSA/TPSA치각유현저차이(t=2.74,P＜0.05),구유교대적감별진단개치.이FPSA/TPSA치≤0.15작위감별진단전렬선암적삼고치,기보지료교고적령민도(91.5%),우제고료특이도(78.6%)화준학솔(79.8%),병재일정정도상제고료양성예측치(82.5%)화음성예측치(96.5%).결론 FPSA/TPSA치불단능구미보단용TPSA적불족,제고전렬선암적조기검출솔,동시감소불필요적활검,치득진일보추엄응용.
Objective To explore the clinical valuation of serum free prostate-specific antigen/total prostate-specific antigen (FPSA/TPSA) ratio in the diagnosis of prostate cancer with time-resolved fluoroimmunoassay. Methods Selected randomly 115 patients with benign prostatic hyperplasia and 58 patients with prostate cancer, sixty healthy physical examinees were chosen as normal control. Serum TPSA, FPSA and FPSA/TPSA ratio were measured with time-resolved fluoroimmunoassay. Results When TPSA was between 4.0- 45.5 μg/L,there was the rang of overlapping of TPSA in benign prostatic hyperplasia and prostate cancer patients. TPSA couldn't be a differential mark for the two conditions (t=1.76, P＞0.05). But there were significant differences in the FPSA/TPSA ratio between the two conditions(t=2.74, P＜0.05). When the reference value was FPSA/TPSA ≤0.15 in differential diagnosis of prostate cancer, it maintained a high sensitivity(91.5% ), improved specificity(78.6%) and reliability(79.8%). It also improved positive predictive value (82.5%) and negative predictive value (96.5%) to a certain extent. Conclusions FPSA/TPSA ratio could make up for the shortage of only TPSA and improved the early detection rate of prostate cancer. It also reduced unnecessary biopsy and worth popularizing.
