中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
CHINESE JOURNAL OF LABORATORY MEDICINE
2012年
3期
243-246
,共4页
王凯飞%沈定霞%刘朝军%叶丽艳%王磊利%张有江
王凱飛%瀋定霞%劉朝軍%葉麗豔%王磊利%張有江
왕개비%침정하%류조군%협려염%왕뢰리%장유강
菌血症%真菌血症%降钙素%蛋白质前体%细菌%念珠菌属%微生物学技术
菌血癥%真菌血癥%降鈣素%蛋白質前體%細菌%唸珠菌屬%微生物學技術
균혈증%진균혈증%강개소%단백질전체%세균%념주균속%미생물학기술
Bacteremia%Fungemia%Calcitonin%Protein precursors%Bacteria%Candida%Microbiological techniques
目的 探讨降钙素原(PCT)定量检测在血流感染患者中的临床应用价值.方法 采用回顾性研究,对解放军总医院1066例患者同时送检血液培养和PCT检测的结果进行分析,其中有效结果1010例.比较血培养结果与血清PCT浓度的关系及PCT浓度在革兰阴性细菌、革兰阳性细菌及假丝酵母菌之间的差异.并且对33例进行过多次PCT检测的血培养阳性患者预后进行了分析.三组间PCT值差异比较采用Mann-Whitney U检验；死亡率比较采用Fisher's精确概率法.结果 血培养阴性患者PCT为0.37(0.11 ～1.67) μg/L.血培养阳性患者PCT水平为2.24(0.57～11.59)μg/L;PCT在革兰阴性细菌、革兰阳性细菌及假丝酵母菌中的阳性率分别为86.6％、72.0％及75.7％.在33例多次PCT检测的血培养阳性患者中,PCT进行性减低者预后较好,PCT均值＞5 μg/L者预后较差.结论 定量检测PCT可作为快速排除和诊断血流感染的辅助检测手段.观察PCT变化趋势对预后判断有一定的参考价值.
目的 探討降鈣素原(PCT)定量檢測在血流感染患者中的臨床應用價值.方法 採用迴顧性研究,對解放軍總醫院1066例患者同時送檢血液培養和PCT檢測的結果進行分析,其中有效結果1010例.比較血培養結果與血清PCT濃度的關繫及PCT濃度在革蘭陰性細菌、革蘭暘性細菌及假絲酵母菌之間的差異.併且對33例進行過多次PCT檢測的血培養暘性患者預後進行瞭分析.三組間PCT值差異比較採用Mann-Whitney U檢驗；死亡率比較採用Fisher's精確概率法.結果 血培養陰性患者PCT為0.37(0.11 ～1.67) μg/L.血培養暘性患者PCT水平為2.24(0.57～11.59)μg/L;PCT在革蘭陰性細菌、革蘭暘性細菌及假絲酵母菌中的暘性率分彆為86.6％、72.0％及75.7％.在33例多次PCT檢測的血培養暘性患者中,PCT進行性減低者預後較好,PCT均值＞5 μg/L者預後較差.結論 定量檢測PCT可作為快速排除和診斷血流感染的輔助檢測手段.觀察PCT變化趨勢對預後判斷有一定的參攷價值.
목적 탐토강개소원(PCT)정량검측재혈류감염환자중적림상응용개치.방법 채용회고성연구,대해방군총의원1066례환자동시송검혈액배양화PCT검측적결과진행분석,기중유효결과1010례.비교혈배양결과여혈청PCT농도적관계급PCT농도재혁란음성세균、혁란양성세균급가사효모균지간적차이.병차대33례진행과다차PCT검측적혈배양양성환자예후진행료분석.삼조간PCT치차이비교채용Mann-Whitney U검험；사망솔비교채용Fisher's정학개솔법.결과 혈배양음성환자PCT위0.37(0.11 ～1.67) μg/L.혈배양양성환자PCT수평위2.24(0.57～11.59)μg/L;PCT재혁란음성세균、혁란양성세균급가사효모균중적양성솔분별위86.6％、72.0％급75.7％.재33례다차PCT검측적혈배양양성환자중,PCT진행성감저자예후교호,PCT균치＞5 μg/L자예후교차.결론 정량검측PCT가작위쾌속배제화진단혈류감염적보조검측수단.관찰PCT변화추세대예후판단유일정적삼고개치.
Objective To evaluate the application value of the quantitative procalcitonin (PCT) test in bloodstream infection.Methods Of 1066 patients with blood culture and PCT detection were collected in our hospital,retrospectively,1010 were effective cases.The relationship between blood culture results and serum PCT levels was investigated.PCT levels in gram-negative bacterial infection,gram-positive bacterial infection and candidiasis were compared.The prognosis of 33 blood culture positive patients with repeated PCT detection results were analyzed.Mann-Whitney U test was used to compare the PCT value among the three groups,and Fisher' s test was used to compare the death rate among the three groups.Results In the patients with negative blood culture results,the median of PCT was 0.37 (0.11 - 1.67) μg/L.But in the patients with positive blood culture results,the median of PCT were 2.24(0.57 -11.59) μg/L The positive rate of PCT in gram-negative bacteria infection,gram-positive bacterial infection and candidiasis were 86.6％,72.0％ and 75.7％,respectively.In the 33 patients subjected to repeated PCT detections,the mortality of the patients with decreasing PCT was lower than the others.The patients whose PCT levels were greater than 5 μg/L had poor prognosis.Conclusions Quantitative PCT is proved to be an effective method for rapid diagnosis of bloodstream infection.The changing trends of PCT test results has certain reference value for the patients' prognosis.
