CAJ | 학술논문

为了探讨补体C5在心肌梗死死后诊断的特异性，应用免疫组织化学和图像分析技术,对正常心脏、心肌梗死及其它非梗死性的引起直接或间接心脏损害的情况如心肌炎、窒息、电击死、出血性休克、心挫伤、有机磷中毒等心肌细胞内C5的变化进行研究。结果发现：C5仅在心肌梗死与心肌炎病例出现阳性反应，其阳性反应面积同正常对照组存在显著性差异，在窒息、电击死、出血性休克、心挫伤、有机磷中毒等病例未见明显阳性反应。因此C5作为心肌梗死死后诊断指标仅受心肌炎的影响，对诊断心肌梗死具有较好的特异性。
위료탐토보체C5재심기경사사후진단적특이성，응용면역조직화학화도상분석기술,대정상심장、심기경사급기타비경사성적인기직접혹간접심장손해적정황여심기염、질식、전격사、출혈성휴극、심좌상、유궤린중독등심기세포내C5적변화진행연구。결과발현：C5부재심기경사여심기염병례출현양성반응，기양성반응면적동정상대조조존재현저성차이，재질식、전격사、출혈성휴극、심좌상、유궤린중독등병례미견명현양성반응。인차C5작위심기경사사후진단지표부수심기염적영향，대진단심기경사구유교호적특이성。
In order to explore the specificity of complement C5 in the postmortem diagnosis of myocardial infarction, changes of C5 staining in normal, infarcted and other non-infarcted myocardia with direct or indirect myocardial injuries (myocarditis, mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion and organophosphate poisoning) were studied with immunohistochemistry and image analysis. The results showed that positive C5 staining could be observed in groups of myocardial infarction and myocarditis, but not in groups of mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion, and organophosphate poisoning. It is indicated that positive reaction of C5 could only be affected by myocarditis, which means that it was more specific for the diagnosis of myocardial infarction.