检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2009年
14期
1143,1145
,共2页
β2-微球蛋白%甲胎蛋白%血清铁蛋白%原发性肝癌
β2-微毬蛋白%甲胎蛋白%血清鐵蛋白%原髮性肝癌
β2-미구단백%갑태단백%혈청철단백%원발성간암
β2-microglobulin%alpha-fetoprotein%serum ferritin
目的 探讨3种肿瘤标志物即β2-微球蛋白(β2-MG)、甲胎蛋白(AFP)、血清铁蛋白(SF)在原发性肝癌临床诊断中的评价.方法 原发性肝癌组100例与健康对照组100例(本院血库正常献血员血清)均采用放射免疫分析法测定血清中β2-MG、AFP、SF抗体浓度,放射免疫试剂盒由中国原子能科学研究院提供,其操作方法按试剂盒上说明书进行.结果 原发性肝癌组血清β2-MG、AFP、SF水平均明显高于健康对照组,差异有统计学意义(P<0.01).β2-MG、AFP、SF阳性率分别为80%、92%、88%;β2-MG与SF联合测定阳性率为90%;AFP与SF联合测定阳性率为88%;三者联合测定阳性率为96%.结论 肿瘤标志物β2-MG、AFP、SF对原发性肝癌有一定的诊断价值[1-2],3种肿瘤标志物联合检测可提高原发性肝癌诊断的敏感性.
目的 探討3種腫瘤標誌物即β2-微毬蛋白(β2-MG)、甲胎蛋白(AFP)、血清鐵蛋白(SF)在原髮性肝癌臨床診斷中的評價.方法 原髮性肝癌組100例與健康對照組100例(本院血庫正常獻血員血清)均採用放射免疫分析法測定血清中β2-MG、AFP、SF抗體濃度,放射免疫試劑盒由中國原子能科學研究院提供,其操作方法按試劑盒上說明書進行.結果 原髮性肝癌組血清β2-MG、AFP、SF水平均明顯高于健康對照組,差異有統計學意義(P<0.01).β2-MG、AFP、SF暘性率分彆為80%、92%、88%;β2-MG與SF聯閤測定暘性率為90%;AFP與SF聯閤測定暘性率為88%;三者聯閤測定暘性率為96%.結論 腫瘤標誌物β2-MG、AFP、SF對原髮性肝癌有一定的診斷價值[1-2],3種腫瘤標誌物聯閤檢測可提高原髮性肝癌診斷的敏感性.
목적 탐토3충종류표지물즉β2-미구단백(β2-MG)、갑태단백(AFP)、혈청철단백(SF)재원발성간암림상진단중적평개.방법 원발성간암조100례여건강대조조100례(본원혈고정상헌혈원혈청)균채용방사면역분석법측정혈청중β2-MG、AFP、SF항체농도,방사면역시제합유중국원자능과학연구원제공,기조작방법안시제합상설명서진행.결과 원발성간암조혈청β2-MG、AFP、SF수평균명현고우건강대조조,차이유통계학의의(P<0.01).β2-MG、AFP、SF양성솔분별위80%、92%、88%;β2-MG여SF연합측정양성솔위90%;AFP여SF연합측정양성솔위88%;삼자연합측정양성솔위96%.결론 종류표지물β2-MG、AFP、SF대원발성간암유일정적진단개치[1-2],3충종류표지물연합검측가제고원발성간암진단적민감성.
Objective To probe the diagnostic value of β2-microglobulin(β2-MG),Alpha-Fetoprotein(AFP),Serum ferritin(SF) in diagnose of primary hepatocellular carcinoma.Methods Two hundred cases were divided into primary hepatocellular carcinoma group(100 cases) and control group(100 cases).Radioimmunoassay (IRMA) was used to detect serum β2-MG,AFP,SF .RIA kits were provided by China Institute of Atomic Energy,and its method of operation be performed according to the kit′s instructions.Results The serum level of β2-MG、AFP and SF in primary hepatocellular carcinoma group were significantly higher than that of control group(P<0.01).The positive rate of β2-MG、AFP and SF for primary hepatocellular carcinoma were 80.0%,92.8%,88.0% respectively. The positive rate of β2-MG and SF tumor markers was 90.0%,the positive rate of AFP and SF tumor markers was 88.0%,and the positive rate of these three tumor markers was 96.0%.Conclusion The three tumor marker have some diagnostic value for primary hepatocellular carcinoma and simultaneously detection is valuable in the diagnosis of primary hepatocellular carcinoma.
