医学分子生物学杂志
醫學分子生物學雜誌
의학분자생물학잡지
FOREIGN MEDICAL SCIENCES
2010年
2期
155-158
,共4页
极小胚胎样干细胞%潜能干细胞%原始生殖干细胞
極小胚胎樣榦細胞%潛能榦細胞%原始生殖榦細胞
겁소배태양간세포%잠능간세포%원시생식간세포
very small embryonic-like stem cells%pluripotent stem cells%primordial germ cells
近年来,研究者从小鼠骨髓和其他组织脏器中分离并纯化了一类数量极其稀少的极小胚胎样干细胞(very small embryonic-like stem cells,VSELs).VSELs不仅表达多能干细胞的表面分子标记,并能向3个胚层方向分化.有学者推测,VSELs可能是在哺乳动物组织/器官的发育早期迁移并定居下来的,且能在特定情况下向组织特异的单潜能干细胞方向分化.据此,VSELs可能在成体组织的更新和损伤组织的再生修复过程中发挥重要作用.
近年來,研究者從小鼠骨髓和其他組織髒器中分離併純化瞭一類數量極其稀少的極小胚胎樣榦細胞(very small embryonic-like stem cells,VSELs).VSELs不僅錶達多能榦細胞的錶麵分子標記,併能嚮3箇胚層方嚮分化.有學者推測,VSELs可能是在哺乳動物組織/器官的髮育早期遷移併定居下來的,且能在特定情況下嚮組織特異的單潛能榦細胞方嚮分化.據此,VSELs可能在成體組織的更新和損傷組織的再生脩複過程中髮揮重要作用.
근년래,연구자종소서골수화기타조직장기중분리병순화료일류수량겁기희소적겁소배태양간세포(very small embryonic-like stem cells,VSELs).VSELs불부표체다능간세포적표면분자표기,병능향3개배층방향분화.유학자추측,VSELs가능시재포유동물조직/기관적발육조기천이병정거하래적,차능재특정정황하향조직특이적단잠능간세포방향분화.거차,VSELs가능재성체조직적경신화손상조직적재생수복과정중발휘중요작용.
Recently,the investigators identified a rare population of very small embryonic-like stem cells(VSELs)from the murine bone marrow and other adult tissues.VSELs not only express several important characteristic biological marker,they may also differentiate among all three germ layers.Some scholars hypothesized that VSELs are deposited during gastrulation and organogenesis in developing organs/tissues of mammals as a population of pluripotent stem cells that give rise to tissue committed monopotent stem cells.Therefore VSELs could play a pivotal role in normal rejuvenation of adult tissues as well as involvement in regeneration of damaged organs.This data will be presented in this review.
