国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2011年
2期
210-213
,共4页
王平%叶志纯%陶利娟%高喜容%谢丽华%杨惠玲%王曦琅
王平%葉誌純%陶利娟%高喜容%謝麗華%楊惠玲%王晞瑯
왕평%협지순%도리연%고희용%사려화%양혜령%왕희랑
高度近视%开角型青光眼%突变%基因%基因测序
高度近視%開角型青光眼%突變%基因%基因測序
고도근시%개각형청광안%돌변%기인%기인측서
high myopia%open angle glaucoma%mutation%genes%gene sequence
目的:在具有家族史的高度近视儿童中进行TIGR基因突变筛查.方法:对高度近视儿童中TIGR基因第三外显子进行毛细血管电泳测序检测,并对结果进行序列分析.结果:在近视组和对照组中均未发现TIGR基因突变.结论:未能发现TIGR基因突变与高度近视相关证据.
目的:在具有傢族史的高度近視兒童中進行TIGR基因突變篩查.方法:對高度近視兒童中TIGR基因第三外顯子進行毛細血管電泳測序檢測,併對結果進行序列分析.結果:在近視組和對照組中均未髮現TIGR基因突變.結論:未能髮現TIGR基因突變與高度近視相關證據.
목적:재구유가족사적고도근시인동중진행TIGR기인돌변사사.방법:대고도근시인동중TIGR기인제삼외현자진행모세혈관전영측서검측,병대결과진행서렬분석.결과:재근시조화대조조중균미발현TIGR기인돌변.결론:미능발현TIGR기인돌변여고도근시상관증거.
AIM: To screen TIGR/myocilin gene (MYOC) mutation in high myopic Chinese children with family history.METHODS: Gene sequencing was performed in exon 3 of the TIGR gene in high myopic Chinese Children. The coding sequence of TIGR exon 3 was screened by capillary electrophoresis sequencing. The sequence alterations were analyzed by bioinformatics.RESULTS: TIGR gene mutation was not found in high myopic patients and normal controls group.CONCLUSION: No identified gene mutation is found in TIGR gene in high myopic Chinese children.
