CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病(COPD)患者第一秒用力呼气容积占用力肺活量百分比(FEV1%)与体质量及血清补体C3、C4的关系。方法：测定27例健康人及40例COPD缓解期患者的体质量、FEV1%及C3、C4。结果：COPD组体质量及C3较健康组低(P<0.001)，C3无差异。FEV1%与体质量及C4水平下降呈正相关(γ=0.517 9,0.527 3)，C4下降与体质量呈正相关(γ=0.487 3)。结论：COPD缓解期患者肺功能损伤与营养不良及C4降低有关，C4及体质量变化是反应COPD程度及预后的指标之一。提示营养干预及免疫支持直接影响对COPD的疗效
목적：탐토만성조새성폐질병(COPD)환자제일초용력호기용적점용력폐활량백분비(FEV1%)여체질량급혈청보체C3、C4적관계。방법：측정27례건강인급40례COPD완해기환자적체질량、FEV1%급C3、C4。결과：COPD조체질량급C3교건강조저(P<0.001)，C3무차이。FEV1%여체질량급C4수평하강정정상관(γ=0.517 9,0.527 3)，C4하강여체질량정정상관(γ=0.487 3)。결론：COPD완해기환자폐공능손상여영양불량급C4강저유관，C4급체질량변화시반응COPD정도급예후적지표지일。제시영양간예급면역지지직접영향대COPD적료효
Objective:To investigate possible correlation between nutritional status and forced expiratory volume in 1 second expressed as percent predicted (FEV1%) and serum levels of complement components C3 and C4 in patients with chronic obstructive pulmonary disease (COPD).Method:Body weight,FEV1% and serum levels of C3 and C4 in 27 healthy subjects and 40 stable COPD patients were determined and studied the correlation between them.Results:Body weight and C4 serum level in COPD group were much lower than that health group,while C3 serum level was no significant.A significant and positive correlation was present between FEV1% and decrease of body weight and C4 level(γ=0.517 9,0.527 3,respectively).Morever,there was significant correlation between body weight and C4 level (γ=0.487 3) in patients with COPD.Conclusion:In patents with stable COPD,pulmonary funciton was associated with the decrease of nutritional depletion (ND) and serum level of complement components C4,which was an indicator of showing the severe degree of COPD and prognosis.These results suggest that nutritional supplementation and immunological supporting treatment directly influence the curative effect of COPD.