CAJ | 학술논문

Krüppel样锌指因子是真核生物中广泛存在的一类转录调控因子,参与细胞分化、增殖、凋亡和肿瘤形成等多种生理病理过程.其结构特点是羧基端高度保守,含有3个C2H2型锌指结构,与富含GC盒或CACCC序列的DNA结合；而氨基端的转录调控区在不同因子之间差异较大,发挥转录激活或转录抑制效应.现有研究显示多个Krüppel样锌指因子成员参与调控各类血细胞的生命活动.此文将就这几个与血液疾病发生有关的KLF样锌指因子作一概述.
Krüppel양자지인자시진핵생물중엄범존재적일류전록조공인자,삼여세포분화、증식、조망화종류형성등다충생리병리과정.기결구특점시최기단고도보수,함유3개C2H2형자지결구,여부함GC합혹CACCC서렬적DNA결합；이안기단적전록조공구재불동인자지간차이교대,발휘전록격활혹전록억제효응.현유연구현시다개Krüppel양자지인자성원삼여조공각류혈세포적생명활동.차문장취저궤개여혈액질병발생유관적KLF양자지인자작일개술.
Krüppel-like factors are an important component of the transcription machinery in eukaryotic cells,which are involved in many physiologic and pathologic processes,including cell proliferation,differentiation,apoptosis and neoplasm transformation.They have a highly conserved domain at carboxyl terminal that binds to GC-rich regions or CACCC sequence in DNA via three C2H2 zinc motifs,whereas their amino terminal is vary greatly and contains transcription regulatory domains to mediate transcriptional activation or repression.Recently,several groups have been identified to control the diverse biological processes of erythrocytes and leukocytes.For example,KLF1 activates β-globin gene expression;KLF2 has been demonstrated to regulate T-cell properties of quiescence and survival ; KLF4,KLF5 and KLF6 are involved in the pathogenesis of blood cell cancers. In this article,we focuses on those KLFs which have new connection with blood disease.