CAJ | 학술논문

肥胖患者下颌及咽周脂肪沉积阻塞气道,可导致阻塞性睡眠呼吸暂停低通气综合征(OSAHS),可能作为OSAHS的预测指标.OSAHS是一种由于睡眠期间反复发生上气道塌陷导致睡眠呼吸暂停以及反复低氧的一种疾病,可引起一系列内分泌和代谢异常.OSAHS患者夜间缺氧可导致脂代谢异常、胰岛素敏感性下降、瘦素抵抗,从而在肥胖的发生、发展中起一定作用.
비반환자하합급인주지방침적조새기도,가도치조새성수면호흡잠정저통기종합정(OSAHS),가능작위OSAHS적예측지표.OSAHS시일충유우수면기간반복발생상기도탑함도치수면호흡잠정이급반복저양적일충질병,가인기일계렬내분비화대사이상.OSAHS환자야간결양가도치지대사이상、이도소민감성하강、수소저항,종이재비반적발생、발전중기일정작용.
Obese patients tend to have mandibular and parapharyngeal fat deposition and airway obstruction,leading to obstructive sleep apnea hypopnea syndrome (OSAHS),which may be used as a predictor of OSAHS.OSAHS is a disease,characterized by recurrent upper airway collapse leading to sleep apnea and repeated hypoxia.It can cause a series of endocrine and metabolic abnormalities.Abnormal lipid metabolism,decline of insulin sensitivity and leptin resistance at midnight in patients with OSAHS play roles in the occurrence and development of obesity.