CAJ | 학술논문

共刺激信号已经成为免疫学研究的一个热点.程序性死亡分子-1(PD-1)及其配体属于抑制性共刺激分子,其在自身免疫性疾病、器官移植排斥反应、病原微生物感染、肿瘤免疫逃逸等方面都发挥着重要作用.近年来,PD-1及其配体(PD-1/PD-L)通路在眼科方面的研究也取得了一定进展.眼部多种疾病和现象,如眼部免疫性疾病、眼部感染性疾病、眼部肿瘤、眼组织的免疫赦免等均发现有PD-1/PD-L通路的改变.这些发现不仅进一步阐明了一些眼部疾病的发病机制,而且为其预防和治疗提供了新的方向.就PD-1/PD-L通路的生物学特性及其在眼科生理病理中的研究进展进行综述.
공자격신호이경성위면역학연구적일개열점.정서성사망분자-1(PD-1)급기배체속우억제성공자격분자,기재자신면역성질병、기관이식배척반응、병원미생물감염、종류면역도일등방면도발휘착중요작용.근년래,PD-1급기배체(PD-1/PD-L)통로재안과방면적연구야취득료일정진전.안부다충질병화현상,여안부면역성질병、안부감염성질병、안부종류、안조직적면역사면등균발현유PD-1/PD-L통로적개변.저사발현불부진일보천명료일사안부질병적발병궤제,이차위기예방화치료제공료신적방향.취PD-1/PD-L통로적생물학특성급기재안과생리병리중적연구진전진행종술.
Costimulatory signals have become a hot field in immunological researches. As co-inhibitory molecules, programmed death-1 ( PD-1) and its ligands (PD-1/PD-L) have been demonstrated to play an important role in autoimmune disease, organ transplant rejection, microorganism infection, tumor immune escapes etc. . In recent years,some studies about PD-1/PD-L pathway in ophthalmology have been curried out and reported. Some changes were found in PD-1/PD-L pathway, such as ocular immunologic diseases, ocular infectious diseases, ocular tumors, immune privilege in ocular tissues and so on. Through the research on PD-1/PD-L pathway,we can further understand the pathogenesis of some ocular diseases and find new methods for their prevention and treatments. This article reviewed the recent advances in PD-1/PD-L pathway in ophthalmological physiopathology.