中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2008年
9期
932-934
,共3页
急性脑梗死%血管内皮细胞生长因子%CD34+细胞
急性腦梗死%血管內皮細胞生長因子%CD34+細胞
급성뇌경사%혈관내피세포생장인자%CD34+세포
Acute cerebral infarction%Vascular endothelial growth factor%CD34+cells
目的 探讨血管内皮生长因子(VEGF)和CD34+细胞在急性脑梗死发病中的变化及作用关系. 方法 分别采取流式细胞仪及酶联免疫法(ELISA)动态测定40例急性脑梗死患者及正常对照者起病后或入组后第3、7、10、14天外周血CD34+细胞和血清VEGF水平.分析其关系. 结果 脑梗死组外周血CD34+细胞水平在各时间点均明显高于对照组,第10天达峰值:脑梗死患者血清VEGF浓度在各时间点亦明显高于对照组,第7-10天达峰值,差异有统计学意义(P<0.05);CD34+细胞水平与血清VEGF浓度两者存在正相关(r=0.452,P<0.01). 结论 脑梗死后外周血VEGF及CD34+细胞水平的升高将促进血管生成,改善脑组织缺血缺氧状态.起到保护神经功能的作用.
目的 探討血管內皮生長因子(VEGF)和CD34+細胞在急性腦梗死髮病中的變化及作用關繫. 方法 分彆採取流式細胞儀及酶聯免疫法(ELISA)動態測定40例急性腦梗死患者及正常對照者起病後或入組後第3、7、10、14天外週血CD34+細胞和血清VEGF水平.分析其關繫. 結果 腦梗死組外週血CD34+細胞水平在各時間點均明顯高于對照組,第10天達峰值:腦梗死患者血清VEGF濃度在各時間點亦明顯高于對照組,第7-10天達峰值,差異有統計學意義(P<0.05);CD34+細胞水平與血清VEGF濃度兩者存在正相關(r=0.452,P<0.01). 結論 腦梗死後外週血VEGF及CD34+細胞水平的升高將促進血管生成,改善腦組織缺血缺氧狀態.起到保護神經功能的作用.
목적 탐토혈관내피생장인자(VEGF)화CD34+세포재급성뇌경사발병중적변화급작용관계. 방법 분별채취류식세포의급매련면역법(ELISA)동태측정40례급성뇌경사환자급정상대조자기병후혹입조후제3、7、10、14천외주혈CD34+세포화혈청VEGF수평.분석기관계. 결과 뇌경사조외주혈CD34+세포수평재각시간점균명현고우대조조,제10천체봉치:뇌경사환자혈청VEGF농도재각시간점역명현고우대조조,제7-10천체봉치,차이유통계학의의(P<0.05);CD34+세포수평여혈청VEGF농도량자존재정상관(r=0.452,P<0.01). 결론 뇌경사후외주혈VEGF급CD34+세포수평적승고장촉진혈관생성,개선뇌조직결혈결양상태.기도보호신경공능적작용.
Objective To investigate the dynamic changes in peripheral blood CD34+cells and plasma levels ofvascular endothelial growth factor(VEGF)in patients with acute cerebral infarction.and explore the roles of CD34+ cells and VEGF in acute cerebral infarcfion. Methods In 40 patients with acute cerebral infarction,the counts of CD34+cells in tlle peripheral blood were measured using flow cytometry on days 3,7,10 and 14 following the onset,with 40 healthy individuals as the control.Plasma levels of VEGF were also measured in these subjects at the same time points using enzyme-linked immunoassay(ELISA). Results Peripheral CD34+ cells increased significantly after the onset of acute cerebral infarction,reaching the peak level on day 10.Plasma VEGF levels also increased significantly in the patients as compared with that in the control subjects,reaching the peak level on days 7to 10.An obvious correlation was noted between the levels of pefipheral blood CD34+cells and VEGF levels in the patients with acute cerebral infarction. Conclusion Increased peripheral VEGF level and CD34+cells folMwing acute cerebral infarction may promote angiogenesis,improve brain tissue hypoxia isehemia,and so play a role in the protection of nerve function.