中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
12期
3-5
,共3页
CA72-4%补体C3a%恶性肿瘤特异性生长因子%贲门癌%肿瘤标志物
CA72-4%補體C3a%噁性腫瘤特異性生長因子%賁門癌%腫瘤標誌物
CA72-4%보체C3a%악성종류특이성생장인자%분문암%종류표지물
CA72-4%Complement C3a%Tumor specific growth factor%Cardiac cancer%Tumor marker
目的 探讨CA72-4、补体C3a和恶性肿瘤特异性生长因子(TSGF)在贲门癌患者血清中的水平,以及三者联合检测在贲门癌临床诊断中的价值.方法 采用电化学发光免疫分析法检测80例贲门癌患者(贲门癌组)、60例贲门良性疾病患者(良性疾病组)、50例健康体检者(对照组)血清中CA72-4、补体C3a、TSGF的浓度,并对单项及联合检测诊断贲门癌的敏感性、特异性、阳性预测值、阴性预测值进行比较,探讨其联合诊断的效能.结果 贲门癌患者血清中CA72-4、补体C3a、TSGF的含量明显高于贲门良性疾病组及健康对照组,差异有统计学意义(P<0.01).联合检测血清CA72-4、C3a和TSGF对贲门癌诊断敏感性为84.6%,特异性为93.8%,阴性预测值91.3%,与单项检测贲门癌敏感性、特异性和阴性预测值相比较,差异有统计学意义(P<0.05).结论 CA72-4、补体C3a、TSGF可作为临床诊断贲门癌的肿瘤标志物,3项联合检测可明显提高贲门癌的诊断敏感性.
目的 探討CA72-4、補體C3a和噁性腫瘤特異性生長因子(TSGF)在賁門癌患者血清中的水平,以及三者聯閤檢測在賁門癌臨床診斷中的價值.方法 採用電化學髮光免疫分析法檢測80例賁門癌患者(賁門癌組)、60例賁門良性疾病患者(良性疾病組)、50例健康體檢者(對照組)血清中CA72-4、補體C3a、TSGF的濃度,併對單項及聯閤檢測診斷賁門癌的敏感性、特異性、暘性預測值、陰性預測值進行比較,探討其聯閤診斷的效能.結果 賁門癌患者血清中CA72-4、補體C3a、TSGF的含量明顯高于賁門良性疾病組及健康對照組,差異有統計學意義(P<0.01).聯閤檢測血清CA72-4、C3a和TSGF對賁門癌診斷敏感性為84.6%,特異性為93.8%,陰性預測值91.3%,與單項檢測賁門癌敏感性、特異性和陰性預測值相比較,差異有統計學意義(P<0.05).結論 CA72-4、補體C3a、TSGF可作為臨床診斷賁門癌的腫瘤標誌物,3項聯閤檢測可明顯提高賁門癌的診斷敏感性.
목적 탐토CA72-4、보체C3a화악성종류특이성생장인자(TSGF)재분문암환자혈청중적수평,이급삼자연합검측재분문암림상진단중적개치.방법 채용전화학발광면역분석법검측80례분문암환자(분문암조)、60례분문량성질병환자(량성질병조)、50례건강체검자(대조조)혈청중CA72-4、보체C3a、TSGF적농도,병대단항급연합검측진단분문암적민감성、특이성、양성예측치、음성예측치진행비교,탐토기연합진단적효능.결과 분문암환자혈청중CA72-4、보체C3a、TSGF적함량명현고우분문량성질병조급건강대조조,차이유통계학의의(P<0.01).연합검측혈청CA72-4、C3a화TSGF대분문암진단민감성위84.6%,특이성위93.8%,음성예측치91.3%,여단항검측분문암민감성、특이성화음성예측치상비교,차이유통계학의의(P<0.05).결론 CA72-4、보체C3a、TSGF가작위림상진단분문암적종류표지물,3항연합검측가명현제고분문암적진단민감성.
Objective To investigate the clinical value of CA72-4, complement C3a and tumor specific growth factor (TSGF) in serum of gastric cancer patients and the significance of their combined detection in diagnosis of cardiac cancer.Methods Serum levels of CA72-4, complement C3a and TSGF were detected using electrochemiluminescence immunoassay (ECL) in 80 patients with cardiac cancer (cardiac group), 60 patients with benign cardiac disease (benign disease), 50 healthy subjects (control group).The diagnostic value of these tumor markers were analyzed by sensitivities, specificities, positive predictive value and negative predictive value with single and joint detection.Results The levels of CA72-4, complement C3a and TSGF in the cardiac cancer group were higher than those in gastric benign disease and normal healthy groups, and the difference was statistically significant (P<0.01). The diagnostic sensitivity of combined detection of serum CA72-4, complement C3a and TSGF for cardiac cancer was 84.6%, specificity was 93.8%, and the negative predictive value was 91.3%, and they were higher than those of the single detection cardiac sensitivity, specificity and negative predictive value, the difference was statistically significant (P<0.05). Conclusions CA72-4, complement C3a and TSGF may be used as the serum tumor markers in the clinical diagnosis of cardiac cancer.The combined detection of three kinds of serum tumor makers can significantly improve the diagnostic sensitivity of cardiac cancer.
